| The activity of the bone isoenzyme of serum alkaline phosphatase and urinary hydroxyproline excretion in premenopausal and postmenopausal women with primary hyperparathyroidism. | |
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MedLine Citation:
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PMID: 6540700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estrogen deficiency might increase responsiveness of bone to circulating endogenous parathormone. To explore a possible relationship between parathormone action on bone and estrogens we studied the activity of the bone isoenzyme of serum alkaline phosphatase and the urinary excretion of hydroxyproline in 16 premenopausal and 24 postmenopausal women with primary hyperparathyroidism with hyperparathyroid osteodystrophy. The postmenopausal women with primary hyperparathyroidism had the B-ALP 4.30 +/- 0.54 mukat/l, the urinary hydroxyproline excretion 205.2 +/- 22.2 mmol/mol creatinine and urinary calcium excretion 8.9 +/- 0.5 mmol/24 hours, significantly increased in comparison with the group of women with menstrual cycle and primary hyperparathyroidism who had B-ALP 2.12 +/- 0.43 mukat/l, the urinary hydroxyproline excretion 119.0 +/- 14.9 mmol/mol creatinine and urinary calcium excretion 7.7 +/- 0.4 mmol/24 hours. Evidence supporting that estrogen deficiency might increase responsiveness of bone to circulating endogenous parathormone was provided by the demonstration that postmenopausal women with primary hyperparathyroidism had increased bone turnover assessed by urinary hydroxyproline excretion and bone isoenzyme of alkaline phosphatase in comparison with the group of premenopausal women with primary hyperparathyroidism. |
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Authors:
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P D Broulik; J Stĕpán; V Pacovský |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental and clinical endocrinology Volume: 83 ISSN: 0232-7384 ISO Abbreviation: Exp. Clin. Endocrinol. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-10-10 Completed Date: 1984-10-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8302802 Medline TA: Exp Clin Endocrinol Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 315-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alkaline Phosphatase / blood* Bone and Bones / enzymology* Calcium / blood Estrogens / blood Female Humans Hydroxyproline / urine* Hyperparathyroidism / metabolism* Isoenzymes / analysis* Menopause* Middle Aged Phosphorus / blood |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Isoenzymes; 51-35-4/Hydroxyproline; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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