Document Detail

The activity of bisphenol A depends on both the estrogen receptor subtype and the cell type.
MedLine Citation:
PMID:  12402979     Owner:  NLM     Status:  MEDLINE    
Bisphenol A (BPA), a monomer of plastic used in consumer products, is abundant in the environment and enters the body by ingestion or adsorption. In order to characterize the estrogenic effect of BPA, we performed luciferase assay on three independent cell lines derived from different tissues transfected with either human ERalpha cDNA or ERbeta cDNA. The estrogenic activities of BPA were detectable in all cell lines via both ERalpha and ERbeta. In 293T cells and Hec-1 cells, the estrogenic activities were significantly decreased when cells expressing ERalpha were incubated with 10(-6) M BPA in the presence of 10(-8) M 17beta-estradiol (E2) while the activities via ERbeta were essentially unchanged in the same conditions. Interestingly, no reduction of estrogenic activity was detected in HOS-TE85 cells via either ERalpha or ERbeta. Our results indicate that BPA only acts as an agonist of estrogen via ERbeta whereas it has dual actions as an agonist and antagonist in some types of cells via ERalpha. Thus, the activity of BPA may depend on the ER subtype and the tissue involved.
Takako Kurosawa; Hisahiko Hiroi; Osamu Tsutsumi; Tomoko Ishikawa; Yutaka Osuga; Toshihiro Fujiwara; Satoshi Inoue; Masami Muramatsu; Mikio Momoeda; Yuji Taketani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine journal     Volume:  49     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-10-29     Completed Date:  2003-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  465-71     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Tokyo, Japan.
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MeSH Terms
Cells, Cultured
Embryo, Mammalian / metabolism
Endometrial Neoplasms / metabolism
Estrogen Receptor alpha
Estrogen Receptor beta
Estrogens / agonists
Estrogens, Non-Steroidal / metabolism*
Kidney / embryology
Osteosarcoma / metabolism
Phenols / metabolism*
Receptors, Estrogen / metabolism*
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Estrogen Receptor beta; 0/Estrogens; 0/Estrogens, Non-Steroidal; 0/Phenols; 0/Receptors, Estrogen; 80-05-7/bisphenol A

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