| Is active sweating during heat acclimation required for improvements in peripheral sweat gland function? | |
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MedLine Citation:
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PMID: 19657101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether the eccrine sweat glands must actively produce sweat during heat acclimation if they are to adapt and increase their capacity to sweat. Eight volunteers received intradermal injections of BOTOX, to prevent neural stimulation and sweat production of the sweat glands during heat acclimation, and saline injections as a control in the contralateral forearm. Subjects performed 90 min of moderate-intensity exercise in the heat (35 degrees C, 40% relative humidity) on 10 consecutive days. Heat acclimation decreased end-exercise heart rate (156 +/- 22 vs. 138 +/- 17 beats/min; P = 0.0001) and rectal temperature (38.2 +/- 0.3 vs. 37.9 +/- 0.3 degrees C; P = 0.0003) and increased whole body sweat rate (0.70 +/- 0.29 vs. 1.06 +/- 0.50 l/h; P = 0.030). During heat acclimation, there was no measurable sweating in the BOTOX-treated forearm, but the control forearm sweat rate during exercise increased 40% over the 10 days (P = 0.040). Peripheral sweat gland function was assessed using pilocarpine iontophoresis before and after heat acclimation. Before heat acclimation, the pilocarpine-induced sweat rate of the control and BOTOX-injected forearms did not differ (0.65 +/- 0.20 vs. 0.66 +/- 0.22 mg x cm(-2) x min(-1)). However, following heat acclimation, the pilocarpine-induced sweat rate in the control arm increased 18% to 0.77 +/- 0.21 mg x cm(-2) x min(-1) (P = 0.021) but decreased 52% to 0.32 +/- 0.18 mg x cm(-2) x min(-1) (P < 0.001) in the BOTOX-treated arm. Using complete chemodenervation of the sweat glands, coupled with direct cholinergic stimulation via pilocarpine iontophoresis, we demonstrated that sweat glands must be active during heat acclimation if they are to adapt and increase their capacity to sweat. |
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Authors:
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Michael J Buono; Travis R Numan; Ryan M Claros; Stephanie K Brodine; Fred W Kolkhorst |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-08-05 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 297 ISSN: 1522-1490 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-10-13 Revised Date: 2010-10-04 |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
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Languages: eng Pagination: R1082-5 Citation Subset: IM |
Affiliation:
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Department of Biology, School of Exercise and Nutritional Sciences, San Diego State University, San Diego, California, USA. mbuono@mail.sdsu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization* Adult Body Temperature Botulinum Toxin Type A / administration & dosage Denervation / methods Eccrine Glands / drug effects, innervation, physiology* Exercise* Female Forearm Heart Rate Hot Temperature* Humans Injections, Intradermal Iontophoresis Male Muscarinic Agonists / administration & dosage Neuromuscular Agents / administration & dosage Pilocarpine / administration & dosage Sweating* / drug effects Time Factors Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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3S06GM64105-01S1/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A; 0/Muscarinic Agonists; 0/Neuromuscular Agents; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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