| The active part of the [6]-gingerol molecule in mutagenesis. | |
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MedLine Citation:
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PMID: 6361533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A study was performed to discover the active part in mutagenesis of [6]-gingerol, a mutagen contained in ginger Zingiber officinale (Nakamura and Yamamoto, 1982). [6]-Shogaol was isolated from the ginger by column chromatography on silica gel. [6]-Shogaol was much less mutagenic (1 X 10(3) revertants/10(8) viable cells/700 microM) than [6]-gingerol (1 X 10(7) of the same units). Mutation frequencies of their related compounds were 4 X 10(1) for zingerone, 1 X 10(7) for 3-hydroxymyristic acid and 3 X 10(2) for 12-hydroxystearic acid. Curcumin, and myristic, stearic and oleic acids had no mutagenicity; and diacetone alcohol and butyroin were suppressible for mutation. It was inferred from these results that the active part of [6]-gingerol was the aliphatic chain moiety containing a hydroxy group. |
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Authors:
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H Nakamura; T Yamamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 122 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1983 Nov |
Date Detail:
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Created Date: 1984-02-14 Completed Date: 1984-02-14 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 87-94 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catechols
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pharmacology Escherichia coli / genetics Fatty Alcohols / isolation & purification, pharmacology* Mutagenicity Tests Mutagens* Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Catechols; 0/Fatty Alcohols; 0/Mutagens; 1391-73-7/gingerol; 555-66-8/shogaol |
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