Document Detail

The active part of the [6]-gingerol molecule in mutagenesis.
MedLine Citation:
PMID:  6361533     Owner:  NLM     Status:  MEDLINE    
A study was performed to discover the active part in mutagenesis of [6]-gingerol, a mutagen contained in ginger Zingiber officinale (Nakamura and Yamamoto, 1982). [6]-Shogaol was isolated from the ginger by column chromatography on silica gel. [6]-Shogaol was much less mutagenic (1 X 10(3) revertants/10(8) viable cells/700 microM) than [6]-gingerol (1 X 10(7) of the same units). Mutation frequencies of their related compounds were 4 X 10(1) for zingerone, 1 X 10(7) for 3-hydroxymyristic acid and 3 X 10(2) for 12-hydroxystearic acid. Curcumin, and myristic, stearic and oleic acids had no mutagenicity; and diacetone alcohol and butyroin were suppressible for mutation. It was inferred from these results that the active part of [6]-gingerol was the aliphatic chain moiety containing a hydroxy group.
H Nakamura; T Yamamoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  122     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
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MeSH Terms
Catechols / pharmacology
Escherichia coli / genetics
Fatty Alcohols / isolation & purification,  pharmacology*
Mutagenicity Tests
Structure-Activity Relationship
Reg. No./Substance:
0/Catechols; 0/Fatty Alcohols; 0/Mutagens; 1391-73-7/gingerol; 555-66-8/shogaol

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