Document Detail

The active management of intrahepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  20124899     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To review the literature regarding the active management of intrahepatic cholestasis of pregnancy. RECENT FINDINGS: There has been an increasing trend toward the active management of cholestasis of pregnancy. This trend exists because clinicians have yet to discover adequate solutions to avert the morbidities and mortalities associated with the disorder. It is believed that early intervention by induction of labor before the 38th week of gestation will decrease the incidence of intrauterine fetal demise associated with cholestasis of pregnancy. It is also believed that treating the clinical symptoms of cholestasis with 2-5 ursodeoxycholic acid will improve maternal symptoms, facilitate the prolongation of pregnancy, and possibly improve fetal outcomes. SUMMARY: The current literature encourages the induction of labor between 37-38 weeks' gestation in order to reduce the incidence of stillbirth in women with intrahepatic cholestasis of pregnancy. The most widely used medication for both the treatment of maternal pruritus and the elevations in maternal liver enzymes associated with cholestasis of pregnancy is 2-5 ursodeoxycholic acid. Neither mode of practice has been subjected to randomized clinical trials.
Jonathan K Mays
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  22     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-3     Citation Subset:  IM    
Department of Obstetrics and Gynecology, New York Medical College, Metropolitan Hospital Center, New York, New York, USA.
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MeSH Terms
Cholestasis, Intrahepatic / complications*,  drug therapy*,  genetics
Labor, Induced
Pregnancy Complications / drug therapy*,  genetics
Pruritus / etiology

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