Document Detail

The activation of red blood cell transketolase in groups of patients especially at risk from thiamin deficiency.
MedLine Citation:
PMID:  3602224     Owner:  NLM     Status:  MEDLINE    
Erythrocyte transketolase activation by thiamin diphosphate has been studied in elderly patients with moderate or severe chronic dementia, acute alcoholic admissions and chronic alcoholics with evidence of brain damage, mostly of the Wernicke-Korsakoff type. Significantly more patients in each group than controls showed abnormal activation of transketolase, not only by 0.3 mM thiamin diphosphate (TDP) but also in further activation by increase to 3 mM. This indicated the presence in a proportion of the alcoholic and the demented patients of an abnormal enzyme variant, similar to that previously found in vitro. The modified transketolase activation test may warn not only of marginal thiamin deficiency but also independently, of susceptibility to brain damage in patients at risk.
M D Jeyasingham; O E Pratt; A Burns; G K Shaw; A D Thomson; A Marsh
Related Documents :
18822684 - Gliosarcomas in the elderly: analysis of 7 cases and clinico-pathological remarks.
11904054 - The effects of mild hypothermia on patients with severe traumatic brain injury.
20413604 - Brain abnormalities on mr imaging in patients with retinoblastoma.
12940844 - Mr imaging of the brain in patients with hepatic form of wilson's disease.
8646274 - Delirium associated with clozapine and benzodiazepine combinations.
24997584 - Serum adenosine deaminase activity in cutaneous anthrax.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  17     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-10     Completed Date:  1987-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Alcohol Amnestic Disorder / enzymology
Alcoholism / enzymology
Dementia / enzymology
Erythrocytes / enzymology*
Middle Aged
Thiamine Deficiency / enzymology*
Transketolase / blood*
Wernicke Encephalopathy / enzymology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of ECT given two vs. three times weekly.
Next Document:  Vasopressin and memory: improvement in normal short-term recall and reduction of alcohol-induced amn...