Document Detail


The activation of red blood cell transketolase in groups of patients especially at risk from thiamin deficiency.
MedLine Citation:
PMID:  3602224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocyte transketolase activation by thiamin diphosphate has been studied in elderly patients with moderate or severe chronic dementia, acute alcoholic admissions and chronic alcoholics with evidence of brain damage, mostly of the Wernicke-Korsakoff type. Significantly more patients in each group than controls showed abnormal activation of transketolase, not only by 0.3 mM thiamin diphosphate (TDP) but also in further activation by increase to 3 mM. This indicated the presence in a proportion of the alcoholic and the demented patients of an abnormal enzyme variant, similar to that previously found in vitro. The modified transketolase activation test may warn not only of marginal thiamin deficiency but also independently, of susceptibility to brain damage in patients at risk.
Authors:
M D Jeyasingham; O E Pratt; A Burns; G K Shaw; A D Thomson; A Marsh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  17     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-08-10     Completed Date:  1987-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alcohol Amnestic Disorder / enzymology
Alcoholism / enzymology
Dementia / enzymology
Erythrocytes / enzymology*
Female
Humans
Male
Middle Aged
Risk
Thiamine Deficiency / enzymology*
Transketolase / blood*
Wernicke Encephalopathy / enzymology
Chemical
Reg. No./Substance:
EC 2.2.1.1/Transketolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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