| The actions of 'selective' excitatory amino acid antagonists on the crustacean neuromuscular junction. | |
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MedLine Citation:
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PMID: 6149495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracellular recordings of neurally evoked excitatory junction potentials were made from the hermit crab neuromuscular junction and the effects of a series of putative antagonists, including the phosphonic amino acids, were examined for their effectiveness. The most potent antagonists were (+/-)2-amino-5-phosphonohexanoic acid and (+/-) 2-amino-5-phosphonovaleric acid while glutamate diethyl ester, DL-alpha-aminoadipate, 2-amino-7-phosphonoheptanoic acid and gamma-D-glutamylglycine were less effective. None of the compounds produced a change in membrane input resistance, but pyridine-2,5-dicarboxylic acid depolarized the muscle membrane and this probably accounted for its apparent antagonist properties. All the compounds readily and reversibly, but not competitively, antagonized the ionophoretic L-glutamate-induced depolarization. Since none of the compounds was capable of producing complete antagonism it is concluded that a more potent and competitive antagonist is required. |
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Authors:
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A E King; H V Wheal |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neuroscience letters Volume: 49 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-11-26 Completed Date: 1984-11-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 217-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Amino-5-phosphonovalerate 2-Aminoadipic Acid / pharmacology Amino Acids / pharmacology Animals Anomura Dipeptides / pharmacology Glutamates / antagonists & inhibitors*, pharmacology Glutamic Acid Neuromuscular Junction / drug effects* Norleucine / analogs & derivatives, pharmacology Pyridines / pharmacology Synaptic Transmission / drug effects* Valine / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Dipeptides; 0/Glutamates; 0/Pyridines; 100-26-5/pyridine-2,5-dicarboxylic acid; 16450-41-2/glutamic acid diethyl ester; 1948-29-4/gamma-glutamylglycine; 5157-09-5/Norleucine; 542-32-5/2-Aminoadipic Acid; 56-86-0/Glutamic Acid; 7004-03-7/Valine; 76726-92-6/2-Amino-5-phosphonovalerate; 78944-89-5/2-amino-6-phosphonohexanoic acid; 85797-13-3/2-amino-7-phosphonoheptanoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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