Document Detail

The action of glycine on rat epileptic foci.
MedLine Citation:
PMID:  7207874     Owner:  NLM     Status:  MEDLINE    
The action of glycine (Gly) intravenously injected on rat epileptic foci induced by strychnine or penicillin topically applied, was compared with that of GABA. Gly (450 mg/kg i.v.) produced a complete block of the spiking activity. The inhibitory action of GABA (80 mg/kg), in terms of threshold and duration, was stronger than the action of Gly. The same inhibitory effect was also observed if these amino acids were applied topically or intracisternally. These results are consistent with the possibility that Gly has a role in the rat cortical inhibition.
E Cherubini; G Bernardi; P Stanzione; M G Marciani; N Mercuri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  21     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  93-7     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Cerebral Cortex / physiology*
Epilepsy / physiopathology*
Glycine / physiology*
gamma-Aminobutyric Acid / physiology
Reg. No./Substance:
56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine

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