Document Detail


The action of equinatoxin, a peptide from the venom of the sea anemone, Actinia equina, on the isolated lung.
MedLine Citation:
PMID:  6147907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
On perfusion through isolated lungs from male Sprague-Dawley rats, equinatoxin caused a dose-dependent increase in the wet to dry weight ratio. Ratios were significantly elevated above control values at equinatoxin concentrations of 80-200 ng/ml. The increased ratios were accompanied by an increase in the permeability of the lung vasculature. When equinatoxin was perfused through isolated lungs at concentrations of 100 ng/ml or greater, significantly more [3H]polyethylene glycol (PEG; approximately 900 mol. wt) was retained in the extravascular space as compared to controls. Perfusion pressures of the lung were significantly elevated above controls at equinatoxin concentrations greater than 100 ng/ml. These effects of equinatoxin were not mediated by degranulation of mast cells, as preperfusion of the lung with 100 or 200 microM Na cromolyn or 1 microM lanthanum chloride did not modify the pulmonary response to equinatoxin. At concentrations of equinatoxin below 150 ng/ml the fluid movement appears to be restricted primarily to intracellular, or possibly interstitial, spaces, as no significant amounts of [3H]polyethylene glycol were recovered by tracheal lavage. At concentrations of equinatoxin equal to or greater than 150 ng/ml, significant amounts of PEG were washed from the trachea. As it is a potent inducer of pulmonary edema, equinatoxin may become an important probe to study fluid regulation in the lung.
Authors:
W M Lafranconi; I Ferlan; F E Russell; R J Huxtable
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  22     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-12     Completed Date:  1984-10-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillary Permeability / drug effects
Cnidarian Venoms / toxicity*
Cromolyn Sodium / pharmacology
Histamine / pharmacology
Lanthanum / pharmacology
Lung / drug effects*
Male
Organ Size / drug effects
Rats
Rats, Inbred Strains
Sea Anemones
Grant Support
ID/Acronym/Agency:
1-T-32-ESO-7091/ES/NIEHS NIH HHS; GM-29277/GM/NIGMS NIH HHS; HL 25258/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cnidarian Venoms; 15826-37-6/Cromolyn Sodium; 51-45-6/Histamine; 54578-46-0/equinatoxin; 7439-91-0/Lanthanum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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