| The action of acetylcholine upon heart rate changes markedly with development in bullfrogs. | |
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MedLine Citation:
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PMID: 3490538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dose-response curves for the action of acetylcholine (ACh) and its antagonist, atropine, upon heart rate in situ were made for three larval stages and adults of the bullfrog, Rana catesbeiana. The absolute magnitude of heart rate inhibition at any ACh concentration progressively increased throughout larval development. Unexpectedly, metamorphosis to the adult resulted in a sharp decrease in cholinergic cardiac sensitivity down to levels similar to the earliest larvae. Thus, cholinergic sensitivity of heart rate, reflecting properties of the cardiac pacemaker, is greatest immediately before metamorphosis and lowest in early larvae and adults. |
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Authors:
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W Burggren; M Doyle |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of experimental zoology Volume: 240 ISSN: 0022-104X ISO Abbreviation: J. Exp. Zool. Publication Date: 1986 Oct |
Date Detail:
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Created Date: 1986-12-16 Completed Date: 1986-12-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375365 Medline TA: J Exp Zool Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
/
antagonists & inhibitors,
pharmacology* Animals Atropine / pharmacology Dose-Response Relationship, Drug Heart Rate / drug effects* Larva Rana catesbeiana / growth & development, physiology* |
| Chemical | |
Reg. No./Substance:
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51-55-8/Atropine; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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