| The acrosome index, radical buffer capacity and number of isolated progressively motile spermatozoa predict IVF results. | |
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MedLine Citation:
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PMID: 11527893 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The accuracy by which a number of newly described semen variables can predict either total fertilization failure (TFF) or pregnancy outcome in IVF, has not previously been investigated. The study aim was, therefore, to determine prospectively the predictive value of these variables. METHODS: The semen variables investigated were the post-wash total progressively motile sperm cell count (TPMC(post-wash)), the acrosome index (AI), 'cytoplasmic residues' and normal sperm morphology, evaluated according to the strict criteria ('strict criteria'), as well as the fast and slow total radical trapping antioxidant potential ('fast TRAP' and 'slow TRAP' respectively). RESULTS: The study group (n = 87) showed a mean (+/- SD) number of 10.2 +/- SD retrieved oocytes, 12.6% TFF, a mean fertilization rate of 59.7% and a pregnancy rate of 19.5% (17/87). TFF was significantly predicted by TPMC(post-wash), 'strict criteria', AI and 'cytoplasmic residues' (all P < 0.05). The outcome after embryo transfer was significantly predicted by AI and 'fast TRAP'. Semen samples with an AI <5% and a 'fast TRAP' <1.14 mmol/l in particular did not result in any pregnancies after IVF-embryo transfer. CONCLUSIONS: Of all the measured and calculated semen variables, TPMC(post-wash) was the best predictor of TFF, whilst AI and 'fast TRAP' were the best predictors of pregnancy after IVF. |
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Authors:
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J P Rhemrev; R Menkveld; T J Roseboom; F W van Overveld; T Teerlink; C Lombard; J P Vermeiden |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 16 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-08-30 Completed Date: 2001-12-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 1885-92 Citation Subset: IM |
Affiliation:
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IVF Centre, Department of Reproductive Medicine, Academic Hospital Vrije Universiteit, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acrosome Reaction* Adult Buffers Female Fertilization Fertilization in Vitro* Forecasting Humans Male Oocytes Predictive Value of Tests Pregnancy Pregnancy Rate Prospective Studies Specimen Handling Sperm Count* Sperm Motility* Treatment Failure Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Buffers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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