Document Detail

Is acid relevant in the genesis of dyspeptic symptoms associated with nonerosive reflux disease?
MedLine Citation:
PMID:  18334866     Owner:  NLM     Status:  MEDLINE    
[table: see text] A consistent subset of patients with NERD suffers from symptoms centered in the upper part of the abdomen that are more characteristic of functional dyspepsia than reflux disease. The cause of this overlap is still unclear, but acid has been implicated as one of the possible common pathophysiological factors responsible for these two categories of upper gastrointestinal (GI) symptoms. Many physiological investigations and the modest success of proton pump inhibitors in resolving dyspeptic symptoms associated with typical reflux syndrome seem to support the concept that functional dyspepsia and NERD are two separate entities, which need to be treated with different drugs.
Vincenzo Savarino; Edoardo Savarino
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  20     ISSN:  0954-691X     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-07-24     Revised Date:  2009-10-16    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  252-4     Citation Subset:  IM    
Gastrointestinal Unit, University of Genova, Genova, Italy.
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MeSH Terms
Dyspepsia / drug therapy,  etiology*,  therapy
Esophageal pH Monitoring / instrumentation
Gastric Acid / physiology,  secretion*
Gastroesophageal Reflux / complications*,  drug therapy
Proton Pump Inhibitors / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Proton Pump Inhibitors
Comment On:
Eur J Gastroenterol Hepatol. 2008 Apr;20(4):264-8   [PMID:  18334868 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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