Document Detail


The acid instability of myelin. A model for myelin degeneration in multiple sclerosis.
MedLine Citation:
PMID:  3398789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electron micrographs of samples of bovine spinal cord which have been briefly acidified (10 mM lactate buffer, pH 5.5, 25 degrees C, 15 minutes) prior to being fixed for EM examination, reveal extensive vesicular disruption of the myelin lamellae; micrographs of control samples incubated under identical conditions at pH 7.0, show normal compact lamellae. Culture of thioglycollate-elicited rat peritoneal macrophages in the presence of derivatized, non-ingestible, bovine CNS material results in the secretion of lactic acid and the acidification of the culture medium to levels which are comparable to those which cause lamellae disruption in the tissue slices. Because of the sensitivity of the myelin lamellae to an acidic microenvironment, it is suggested that a local hyperlactemia, with the resulting decrease in interstitial pH, may be a major pathological process in cell-mediated inflammatory demyelination. Antihyperlactemics may therefore provide a new therapeutic approach to minimizing myelin degeneration in multiple sclerosis and in other CNS disorders characterized by inflammatory demyelination.
Authors:
P R Young; W R Snyder; D A Vacante; C M Waickus; A P Zygas; F Grynspan; C Karunatilake; D H Wilson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical hypotheses     Volume:  26     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-09-01     Completed Date:  1988-09-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Illinois at Chicago 60680.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Cells, Cultured
Hydrogen-Ion Concentration
Lactates / secretion*
Lactic Acid
Macrophages / metabolism
Multiple Sclerosis / metabolism,  pathology*
Myelin Sheath / metabolism,  ultrastructure*
Rats
Rats, Inbred Strains
Spinal Cord / ultrastructure
Grant Support
ID/Acronym/Agency:
NS00775/NS/NINDS NIH HHS; NS17094/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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