| The acid instability of myelin. A model for myelin degeneration in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 3398789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Electron micrographs of samples of bovine spinal cord which have been briefly acidified (10 mM lactate buffer, pH 5.5, 25 degrees C, 15 minutes) prior to being fixed for EM examination, reveal extensive vesicular disruption of the myelin lamellae; micrographs of control samples incubated under identical conditions at pH 7.0, show normal compact lamellae. Culture of thioglycollate-elicited rat peritoneal macrophages in the presence of derivatized, non-ingestible, bovine CNS material results in the secretion of lactic acid and the acidification of the culture medium to levels which are comparable to those which cause lamellae disruption in the tissue slices. Because of the sensitivity of the myelin lamellae to an acidic microenvironment, it is suggested that a local hyperlactemia, with the resulting decrease in interstitial pH, may be a major pathological process in cell-mediated inflammatory demyelination. Antihyperlactemics may therefore provide a new therapeutic approach to minimizing myelin degeneration in multiple sclerosis and in other CNS disorders characterized by inflammatory demyelination. |
| | |
Authors:
|
P R Young; W R Snyder; D A Vacante; C M Waickus; A P Zygas; F Grynspan; C Karunatilake; D H Wilson |
Related Documents
:
|
18951889 - Epithelial na+ channel delta subunit is an acid sensor in the human oesophagus. 18964029 - Study of ph and substrate effects on room-temperature phosphorimetry of some indolecarb... 11205049 - Ph regulation in isolated in vitro perfused rat colonic crypts. 2551179 - Ph regulation in hepatoma cells: roles for na-h exchange, cl-hco3 exchange, and na-hco3... 15963369 - Acid neutralization within limestone sand reactors receiving coal mine drainage. 15486709 - Analysis of tnt (2,4,6-trinitrotoluene)-inducible cellular responses and stress shock p... 20083229 - Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic ... 7775019 - Amino-acid conjugates of the hapten 2-phenyl-4-ethoxymethylene-5(4h)-oxazolone. synthes... 12926259 - Synthesis of (r)-2-methyl-4-deoxy and (r)-2-methyl-4,5-dideoxy analogues of 6-phosphogl... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Medical hypotheses Volume: 26 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1988 May |
Date Detail:
|
Created Date: 1988-09-01 Completed Date: 1988-09-01 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 31-7 Citation Subset: IM |
Affiliation:
|
Department of Chemistry, University of Illinois at Chicago 60680. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cattle Cells, Cultured Hydrogen-Ion Concentration Lactates / secretion* Lactic Acid Macrophages / metabolism Multiple Sclerosis / metabolism, pathology* Myelin Sheath / metabolism, ultrastructure* Rats Rats, Inbred Strains Spinal Cord / ultrastructure |
| Grant Support | |
ID/Acronym/Agency:
|
NS00775/NS/NINDS NIH HHS; NS17094/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Lactates; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A theoretical design for a contact lens tonometer.
Next Document: Neuropharmacologic control of cerebral capillary permeability: current implications for therapy of v...