Document Detail


Ethinylestradiol/chlormadinone acetate.
MedLine Citation:
PMID:  15025547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ethinylestradiol/chlormadinone acetate 0.03/2mg (EE/CMA) is a combined monophasic contraceptive pill with antiandrogenic properties. In a large, noncomparative, multicentre trial (< or =24 cycles of treatment per woman) and two (6- and 12-cycle) postmarketing surveillance studies, EE/CMA was effective in preventing pregnancy. EE/CMA was significantly more effective than EE/levonorgestrel 0.03/0.15 mg/day in treating women with mild-to-moderate papulopustular acne of the face and related disorders in a randomised, single-blind, multicentre trial. EE/CMA was well tolerated in clinical trials and the postmarketing surveillance studies. Adverse events were those commonly reported with oral contraceptives. As expected, the most common menstrual disturbances were breakthrough bleeding, spotting and amenorrhoea.
Authors:
Monique P Curran; Antona J Wagstaff
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Drugs     Volume:  64     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-17     Completed Date:  2004-08-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  751-60; discussion 761-2     Citation Subset:  IM    
Affiliation:
Adis International Limited, 41 Centorian Drive, PB 65901, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz
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MeSH Terms
Descriptor/Qualifier:
Chlormadinone Acetate / analogs & derivatives,  therapeutic use*
Clinical Trials, Phase III as Topic
Contraceptives, Oral, Combined / pharmacokinetics,  pharmacology,  therapeutic use*
Controlled Clinical Trials as Topic
Drug Therapy, Combination*
Endometrium / drug effects
Ethinyl Estradiol / analogs & derivatives,  therapeutic use*
Fallopian Tubes / drug effects,  physiology
Female
Germany
Humans
Pituitary Diseases / drug therapy*
Chemical
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 0/ethinylestradiol-chlormadinone acetate; 302-22-7/Chlormadinone Acetate; 57-63-6/Ethinyl Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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