Document Detail

An accurate measure of the instantaneous discharge probability, with application to unitary joint-even analysis.
MedLine Citation:
PMID:  10769325     Owner:  NLM     Status:  MEDLINE    
We present an estimate for the instantaneous discharge probability of a neurone, based on single-trial spike-train analysis. By detecting points where the neurone abruptly changes its firing rate and treating them specially, the method is able to achieve smooth estimates yet avoid the blurring of significant changes. This estimate of instantaneous discharge probability is then applied to the method of unitary event analysis. We show that the unitary event analysis as originally conceived is highly sensitive to firing-rate nonstationarities and covariations, but that it can be considerably improved if calculations of statistical significance use an instantaneous discharge probability instead of a firing-rate estimate based on averaging across multiple trials.
Q Pauluis; S N Baker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neural computation     Volume:  12     ISSN:  0899-7667     ISO Abbreviation:  Neural Comput     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-18     Completed Date:  2000-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9426182     Medline TA:  Neural Comput     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-69     Citation Subset:  IM    
Laboratory of Neurophysiology, School of Medicine, Université Catholique de Louvain Brussels, Belgium.
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MeSH Terms
Action Potentials / physiology*
Models, Neurological*
Motor Cortex / cytology,  physiology
Neurons / physiology*

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