| The accuracy of whole brain N-acetylaspartate quantification. | |
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MedLine Citation:
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PMID: 11167045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A non-localizing pulse sequence to quantify the total amount of N-acetylaspartate (NAA) in the whole brain (WBNAA) was introduced recently [Magn. Reson. Med. 40, 684-689 (1998)]. However, it is known that regional magnetic field inhomogeneities, deltaB0s, arising from susceptibility differences at tissue interfaces, shift and broaden local resonances to outside the integration window, leading to an underestimation of the true amount of NAA in the entire brain. To quantify the upper limit of this loss, the whole-head proton MR spectrum (1H-MRS) of the water was integrated over the same frequency width as the NAA. The ratio of this area/total-water-line was 75 +/- 5% in 5 volunteers. The procedure was repeated with the brain-only water peak, obtained by summing signals only from voxels within that organ from a three-dimensional chemical-shift-imaging (3D CSI) set. It indicated that <10% of the water signal loss occurred in the brain. Therefore, by analogy, WBNAA accounts for >90% of that metabolite. |
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Authors:
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O Gonen; R I Grossman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Magnetic resonance imaging Volume: 18 ISSN: 0730-725X ISO Abbreviation: Magn Reson Imaging Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-05-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8214883 Medline TA: Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 1255-8 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania 19104, USA. oded@rad.upenn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspartic Acid / analogs & derivatives*, analysis* Brain / metabolism* Brain Chemistry Female Humans Magnetic Resonance Spectroscopy* Male Protons Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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NS29029/NS/NINDS NIH HHS; NS33385/NS/NINDS NIH HHS; NS37739/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Protons; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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