| The accumulation and elimination of tissue residues after feeding pentachloronitrobenzene to White Leghorn cockerels. | |
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MedLine Citation:
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PMID: 751034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Day-old White Leghorn cockerels were fed graded levels (10, 50, 100, and 1000 ppm) of pentachloronitrobenzene (PCNB) containing pentachlorobenzene (PCB), tetrachloronitrobenzene (TCNB), and hexachlorobenzene (HCB) at trace contaminants, for 12 weeks. Bioaccumulation of PCNB and its metabolites in tissues does not appear to occur to any major extent. The contaminants of PCNB, HCB, and PCB were found to accumulate to a greater degree in adipose tissue than does PCNB itself. TCNB was also detected in adipose tissue and in trace amounts in other tissues. PCNB accumulated to the highest concentration in body fat followed by gizzard and kidney. Only traces of PCNB were found in heart, liver, leg, and heart muscle. Metabolites, pentachloroaniline (PCA), and pentachlorphenylmethylsulfide (PCMS) were found in only trace quantities following the feeding of 1000 ppm PCNB. Half-life values for the depletion of the contaminants of PCNB, PCB, and HCB were determined in adipose tissue of cockerels; values as high as 53 and 95 days were found for PCB and HCB, respectively. |
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Authors:
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J S Dunn; N H Booth; P B Bush; R L Farrell; D Thomason; D D Goetsch |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Poultry science Volume: 57 ISSN: 0032-5791 ISO Abbreviation: Poult. Sci. Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-07-16 Completed Date: 1979-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401150 Medline TA: Poult Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1533-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Animals Chickens / metabolism* Chlorobenzenes / metabolism* Hexachlorobenzene / metabolism Male Muscles / metabolism Nitrobenzenes / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Chlorobenzenes; 0/Nitrobenzenes; 118-74-1/Hexachlorobenzene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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