Document Detail

The accumulation and elimination of tissue residues after feeding pentachloronitrobenzene to White Leghorn cockerels.
MedLine Citation:
PMID:  751034     Owner:  NLM     Status:  MEDLINE    
Day-old White Leghorn cockerels were fed graded levels (10, 50, 100, and 1000 ppm) of pentachloronitrobenzene (PCNB) containing pentachlorobenzene (PCB), tetrachloronitrobenzene (TCNB), and hexachlorobenzene (HCB) at trace contaminants, for 12 weeks. Bioaccumulation of PCNB and its metabolites in tissues does not appear to occur to any major extent. The contaminants of PCNB, HCB, and PCB were found to accumulate to a greater degree in adipose tissue than does PCNB itself. TCNB was also detected in adipose tissue and in trace amounts in other tissues. PCNB accumulated to the highest concentration in body fat followed by gizzard and kidney. Only traces of PCNB were found in heart, liver, leg, and heart muscle. Metabolites, pentachloroaniline (PCA), and pentachlorphenylmethylsulfide (PCMS) were found in only trace quantities following the feeding of 1000 ppm PCNB. Half-life values for the depletion of the contaminants of PCNB, PCB, and HCB were determined in adipose tissue of cockerels; values as high as 53 and 95 days were found for PCB and HCB, respectively.
J S Dunn; N H Booth; P B Bush; R L Farrell; D Thomason; D D Goetsch
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Poultry science     Volume:  57     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  1978 Nov 
Date Detail:
Created Date:  1979-07-16     Completed Date:  1979-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1533-8     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / metabolism
Chickens / metabolism*
Chlorobenzenes / metabolism*
Hexachlorobenzene / metabolism
Muscles / metabolism
Nitrobenzenes / metabolism*
Reg. No./Substance:
0/Chlorobenzenes; 0/Nitrobenzenes; 118-74-1/Hexachlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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