Document Detail


The absence of a mucosal lesion on standard histological examination does not exclude diagnosis of celiac disease.
MedLine Citation:
PMID:  17487584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some patients with undiagnosed celiac disease have minor mucosal lesions that may not be apparent during routine histological analysis. Twenty-five such patients of our institution were discharged to their primary-care physicians despite having positive endomysial antibody serology. To re-evaluate diagnosis for these patients, immunohistological staining with antibodies to CD2, CD3, CD7, CD8, CD69, and Ki67 was conducted on original biopsies from twenty patients. Clinical, serological, and histological investigations were offered to all fourteen patients who attended for review. We observed a significantly greater (P < 0.0001) numbers of intraepithelial lymphocytes and Ki67-positive enterocytes in sections from these twenty patients than for normal controls. Of the fourteen patients who attended for further review, firm diagnosis of celiac disease was made for seven patients and diagnosis was likely for another two. Our study clearly revealed that over-reliance on standard histological findings results in failure to diagnose celiac disease.
Authors:
Bashir M Mohamed; Conleth Feighery; Christian Coates; Una O'Shea; David Delaney; Seán O'Briain; Jacinta Kelly; Mohamed Abuzakouk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-09
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  52-61     Citation Subset:  AIM; IM    
Affiliation:
Department of Immunology, St James's Hospital and Trinity College Dublin, Dublin, 8, Ireland. mohamebm@tcd.ie
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, CD / immunology
Biopsy
Celiac Disease / diagnosis*,  immunology
Diagnosis, Differential
Duodenum / immunology,  pathology*
Female
Follow-Up Studies
Humans
Immunohistochemistry
Intestinal Mucosa / immunology,  pathology*
Male
Middle Aged
Retrospective Studies
Chemical
Reg. No./Substance:
0/Antigens, CD

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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