Document Detail


An absence of human leukocyte antigen-DR and a decreased expression of beta 2-microglobulin on tumor cells of basal cell carcinoma: no influence on the peritumoral immune infiltrate.
MedLine Citation:
PMID:  2521495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression of human leukocyte antigen-DR (HLA-DR) and beta 2-microglobulin on the tumor cells and their correlation (if any) to the degree and the composition of the peritumoral mononuclear infiltrate were studied in 37 basal cell carcinomas from 32 patients with an indirect immunoperoxidase technique. In 36 of 37 basal cell carcinomas (97%) there was no expression of HLA-DR on tumor cells of basal cell carcinoma. In 13 of 37 basal cell carcinomas (35%) beta 2-microglobulin was expressed on the tumor cells. Both a diffuse cytoplasmic and a membrane staining were observed in only six of these 13 basal a diffuse cytoplasmic and a membrane staining were observed in only six of these 13 basal cell carcinomas; in the other seven basal cell carcinomas only a diffuse cytoplasmic staining was observed. In all 37 basal cell carcinomas there was membrane staining for beta 2-microglobulin in the normal epidermis. The intensity of staining in the normal epidermis was always stronger than that in the tumor nests. There was a varying degree of peritumoral immune infiltrate in all basal cell carcinomas. It comprised mainly T cells (mean percentage 57 +/- 15). In the group of patients with basal cell carcinoma with moderate to heavy infiltrate the mean percentage of T cells was 63 +/- 13, which was significantly higher than the mean percentage of T cells (46% +/- 14%) in the group of patients with basal cell carcinoma with a mild infiltrate. This difference was mainly the result of an increase in T helper cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J M Habets; B Tank; V D Vuzevski; E Stolz; T van Joost
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  20     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-03-06     Completed Date:  1989-03-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-52     Citation Subset:  IM    
Affiliation:
Department of Dermato-Venereology, Erasmus University Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Antigens, Neoplasm / analysis*
Carcinoma, Basal Cell / analysis,  pathology*
Epidermis / pathology
HLA-DR Antigens / analysis*
Humans
Immunoenzyme Techniques
Middle Aged
Skin Neoplasms / analysis,  pathology*
T-Lymphocytes / pathology*
T-Lymphocytes, Cytotoxic / pathology
T-Lymphocytes, Helper-Inducer / pathology
T-Lymphocytes, Regulatory / pathology
beta 2-Microglobulin / analysis*
Chemical
Reg. No./Substance:
0/Antigens, Neoplasm; 0/HLA-DR Antigens; 0/beta 2-Microglobulin

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