Document Detail


The absence of confronting cisternae following thymidine-induced synchronization in HeLa cells.
MedLine Citation:
PMID:  8374597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This is the first report of the elimination of confronting cisternae (CC), prominent organelles in dividing HeLa cells, upon experimental manipulation of the cells. CC are lost when a double thymidine block is employed to synchronize cell division. This observation is consistent with the hypothesis that the occurrence of CC in some fetal cells and in selected tumor cells depends on the speed at which the cells cycle through mitosis. If thymidine blocks DNA synthesis and arrests cells at the G1/S interface, then thymidine probably has an indirect effect on CC. This paper reports the effect of thymidine on the occurrence of CC and briefly discusses how inhibitors of membrane synthesis or microtubule polymerization may affect the occurrence of CC during mitosis.
Authors:
J R Palisano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell biology international     Volume:  17     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-21     Completed Date:  1993-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  653-64     Citation Subset:  IM    
Affiliation:
Department of Biology, University of South Sweanee, Tennessee.
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MeSH Terms
Descriptor/Qualifier:
Cell Division / drug effects
Hela Cells
Humans
Microscopy, Electron
Organelles / drug effects*,  ultrastructure*
Thymidine / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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