| The absence of a catechol estrogen effect on blood pressure in the male rat. | |
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MedLine Citation:
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PMID: 6098975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since catechol estrogens are potent competitive inhibitors of catechol-O-methyl transferase (COMT), it has been suggested that they may prolong the half-life of catecholamines which in turn can cause hypertension. Thus, experiments were carried out to study the effect of catechol estrogens on blood pressure in the male rat following chronic administration. Results demonstrate that 2-hydroxyesterone (2,3-dihydroxyestra-1,3,5(10)-trien-17-one) and 2-hydroxy-estradiol (estra-1,3,5(10)-triene-2,3,17 beta-triol) even when administered in high doses do not alter blood pressure. |
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Authors:
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S C Chattoraj; D J Cecchini; T F Brennan; K C Edelin; A V Chobanian; H H Wotiz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Steroids Volume: 42 ISSN: 0039-128X ISO Abbreviation: Steroids Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1985-04-03 Completed Date: 1985-04-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 603-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Catechol O-Methyltransferase / antagonists & inhibitors Drug Implants Estradiol / analogs & derivatives, pharmacology Estrogens, Catechol / pharmacology* Hydroxyestrones / blood, pharmacology Male Rats |
| Grant Support | |
ID/Acronym/Agency:
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CA 28856-01/CA/NCI NIH HHS; HD 11223/HD/NICHD NIH HHS; HL 18318/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drug Implants; 0/Estrogens, Catechol; 0/Hydroxyestrones; 362-05-0/2-hydroxyestradiol; 362-06-1/2-hydroxyestrone; 50-28-2/Estradiol; EC 2.1.1.6/Catechol O-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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