| The absence of ABCD2 sensitizes mice to disruptions in lipid metabolism by dietary erucic acid. | |
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MedLine Citation:
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PMID: 22493092 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABCD2 (D2) is a peroxisomal transporter that is highly abundant in adipose tissue and promotes the oxidation of long-chain monounsaturated fatty acids (MUFA). Erucic acid (EA, 22:1ω9) reduces very long chain saturated fatty acids (VLCFA) in patients with X-linked Adrenoleukodystrophy (ALD), but promotes dyslipidemia and dilated cardiomyopathy in rats. To determine the role of D2 the metabolism of EA, we challenged wild-type and D2 deficient mice (D2 KO) with an enriched EA diet. In D2 KO mice, dietary EA resulted in the rapid expansion of adipose tissue, adipocyte hypertrophy, hepatic steatosis and the loss of glycemic control. However, D2 had no impact on the development of obesity phenotypes in two models of diet-induced obesity. Although there was a significant increase in EA in liver of D2 KO mice, it constituted less than 2% of all fatty acids. Metabolites of EA (20:1, 18:1, and 16:1) were elevated, particularly 18:1 which accounted for 50% of all fatty acids. These data indicate that the failure to metabolize EA in adipose results in hepatic metabolism of EA, disruption of the fatty acid profile, and the development of obesity and reveal an essential role for D2 in the protection from dietary EA. |
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Authors:
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Jingjing Liu; Shuang Liang; Xiaoxi Liu; J Andrew Brown; Kylie E Newman; Manjula Sunkara; Andrew J Morris; Saloni Bhatnagar; Xiangan Li; Aurora Pujol; Gregory A Graf |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-6 |
Journal Detail:
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Title: Journal of lipid research Volume: - ISSN: 0022-2275 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376606 Medline TA: J Lipid Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Kentucky, United States; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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