Document Detail

The abolition of the partial reinforcement extinction effect (PREE) by amphetamine: disruption of control by nonreinforcement.
MedLine Citation:
PMID:  3628434     Owner:  NLM     Status:  MEDLINE    
Two groups of rats were trained to run in a straight alley. The continuously reinforced (CRF) group received a food reward on every trial. The partially reinforced (PRF) group was rewarded on a quasi-random 50% schedule. d-Amphetamine 1 mg/kg was administered to PRF animals in acquisition in a 2 X 2 design, i.e., drug-no drug on reinforced trials and drug-no drug on nonreinforced trials. In four CRF groups, the drug was administered in the same sequence as in the PRF groups. Following acquisition, all animals were given 4 days of CRF retraining and tested in extinction. No drug was given in retraining and extinction. The PREE, i.e., increased resistance exhibited by PRF animals as compared to CRF animals, was obtained in groups which received placebo on all acquisition trials or amphetamine on rewarded trials and placebo on nonrewarded trials. The PREE was abolished when amphetamine was administered throughout the acquisition trials or on nonrewarded trials, irrespective of drug treatment on rewarded trials.
I Weiner; J Feldon; H Bercovitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  27     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-09-25     Completed Date:  1987-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
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MeSH Terms
Dextroamphetamine / pharmacology*
Extinction, Psychological / drug effects*
Learning / drug effects
Rats, Inbred Strains
Reinforcement Schedule*
Reg. No./Substance:

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