Document Detail

The abnormal pulmonary venous connexion: a developmental approach.
MedLine Citation:
PMID:  2283187     Owner:  NLM     Status:  MEDLINE    
If embryonic communications exist between the splanchnic and cardinal venous systems, then they can explain variations in partially or completely abnormal pulmonary venous return as seen in congenitally malformed hearts. With this in mind, we investigated complete serial sections of 52 human embryos, ranging from 4.4 to 25 mm crown-rump length (Streeter's horizons XIII-XXII) and 57 mouse embryos (Mus musculus albus CPB-S) from 7.8 to 19.7 days of gestation. Specifically, we investigated whether communications persisted between the splanchnic, the pulmonary and the cardinal venous systems. In the early stages of development, the pulmonary vascular bed shared the route of drainage of the peripheral splanchnic plexus into the umbilical-vitelline and cardinal venous systems. As the pulmonary plexus developed, it obtained a new direct route of drainage into the left atrium via the pulmonary veins. A persistence of embryonic connexions was encountered in one human and 14 mouse embryos. In all these cases, the stage of development was such that the connexions between the splanchnic and pulmonary plexuses should have disappeared. An abnormality in the development of the central pulmonary venous system was also found in the human embryo. Whether this was primary or secondary to the persistence of the embryonic connexions remained unresolved.
S Rammos; A C Gittenberger-de Groot; A Oppenheimer-Dekker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  29     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-20     Completed Date:  1991-03-20     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
Department of Pediatric Cardiology, Heinrich-Heine University of Düsseldorf, F.R.G.
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MeSH Terms
Heart / embryology
Pulmonary Veins / abnormalities,  embryology*
Splanchnic Circulation

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