Document Detail

The ability of non-invasive physiological tests to detect arterial occlusions in the lower extremity. An ROC study with particular regard to recruitment of patients for clinical trials.
MedLine Citation:
PMID:  9789972     Owner:  NLM     Status:  MEDLINE    
In the prerandomization phase of a clinical trial it is essential to be able to exclude, in a non-invasive way, patients who cannot be randomized into the trial. The ability of routine non-invasive physiological examinations to detect arterial occlusion in the lower extremities was investigated in 182 patients with hypercholesterolaemia. Ankle blood pressure measurement, pulse oscillometry, digital pulse plethysmography and treadmill and cycle exercise tests were performed as part of the prerandomization phase of the Probucol Quantitative Regression Swedish Trial (PQRST). The PQRST was designed to compare the antiatherosclerotic effect of two different lipid-lowering regimens. Before randomization the patients also underwent aorto-femoral arteriography, which was used as 'gold standard'. The results were analysed with ROC methodology. Ankle blood pressure measurement (ABP) and inclination time (IT), measured with digital pulse plethysmography, without significant mutual difference, were the variables, best able to detect occlusions. For ABP, the AZ-values were 0.85, 0.82 and 0.94 in detection of right-sided, left-sided and bilateral occlusion, respectively. The corresponding figures for IT were AZ = 0.86, 0.91 and 0.93. If a bilateral occlusion was predicted in a patient with an ABP value of < = or 0.98, a specificity of 0.90 and a sensitivity of 0.87 were obtained, using arteriography as reference method. For IT, with a critical value of 320 ms, sensitivity and specificity were 0.83 and 0.90, respectively.
S Nilsson; U Eriksson; J Johansson; L Kaijser; C Lassvik; J Mölgaard; A G Olsson; G Walldius
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Upsala journal of medical sciences     Volume:  103     ISSN:  0300-9734     ISO Abbreviation:  Ups. J. Med. Sci.     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-23     Completed Date:  1998-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0332203     Medline TA:  Ups J Med Sci     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  61-75     Citation Subset:  IM    
Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Ankle / physiology
Arterial Occlusive Diseases / diagnosis*
Blood Pressure
Double-Blind Method
Leg / blood supply*
Middle Aged
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Evidence of cerebral dysfunction associated with isoflurane- or propofol based anaesthesia for ortho...
Next Document:  Experimental transmission of white spot syndrome virus (WSSV) from crabs to shrimp Penaeus monodon.