| The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients. | |
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MedLine Citation:
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PMID: 9084068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study, we reported that Alzheimer disease (AD) patients with an apolipoprotein E (APOE) epsilon 4 allele (+ APOE4) show more severe loss of nucleus basalis (NB) cholinergic cells than patients without epsilon 4 alleles (-APOE4). The present study investigates the effects of a single oral administration of THA 25 or 50 mg on cortical spectral EEG activity in + (five APOE4/4, six APOE4/3) and -APOE4 (eight APOE3/3) AD patients. THA 25 mg had no significant effect on EEG activity in any AD patients. However, THA 50 mg increased alpha activity and alpha/theta ratio in -APOE4 patients. In contrast, THA 50 mg had no effect on EEG activity in + APOE4 patients. This result tentatively suggests that in AD patients APOE genotype may affect the response of cortical electrical arousal to cholinergic therapy that enhances the efficacy of presynaptic NB axons. |
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Authors:
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P Riekkinen; H Soininen; J Partanen; A Pääkkönen; S Helisalmi; P Riekkinen |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Psychopharmacology Volume: 129 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-11-19 Completed Date: 1997-11-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 285-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital of Kuopio, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alpha Rhythm / drug effects* Alzheimer Disease / drug therapy*, genetics, physiopathology Apolipoproteins E / genetics* Cholinesterase Inhibitors / therapeutic use* Double-Blind Method Genotype Humans Middle Aged Tacrine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E; 0/Cholinesterase Inhibitors; 321-64-2/Tacrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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