Document Detail

The ability of THA treatment to increase cortical alpha waves is related to apolipoprotein E genotype of Alzheimer disease patients.
MedLine Citation:
PMID:  9084068     Owner:  NLM     Status:  MEDLINE    
In a previous study, we reported that Alzheimer disease (AD) patients with an apolipoprotein E (APOE) epsilon 4 allele (+ APOE4) show more severe loss of nucleus basalis (NB) cholinergic cells than patients without epsilon 4 alleles (-APOE4). The present study investigates the effects of a single oral administration of THA 25 or 50 mg on cortical spectral EEG activity in + (five APOE4/4, six APOE4/3) and -APOE4 (eight APOE3/3) AD patients. THA 25 mg had no significant effect on EEG activity in any AD patients. However, THA 50 mg increased alpha activity and alpha/theta ratio in -APOE4 patients. In contrast, THA 50 mg had no effect on EEG activity in + APOE4 patients. This result tentatively suggests that in AD patients APOE genotype may affect the response of cortical electrical arousal to cholinergic therapy that enhances the efficacy of presynaptic NB axons.
P Riekkinen; H Soininen; J Partanen; A Pääkkönen; S Helisalmi; P Riekkinen
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  129     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-11-19     Completed Date:  1997-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  285-8     Citation Subset:  IM    
Department of Neurology, University Hospital of Kuopio, Finland.
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MeSH Terms
Alpha Rhythm / drug effects*
Alzheimer Disease / drug therapy*,  genetics,  physiopathology
Apolipoproteins E / genetics*
Cholinesterase Inhibitors / therapeutic use*
Double-Blind Method
Middle Aged
Tacrine / therapeutic use*
Reg. No./Substance:
0/Apolipoproteins E; 0/Cholinesterase Inhibitors; 321-64-2/Tacrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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