Document Detail

Is abietic acid the allergenic component of colophony?
MedLine Citation:
PMID:  4085221     Owner:  NLM     Status:  MEDLINE    
In order to investigate whether abietic acid itself is the allergenic component of colophony, 2 commercial samples were extensively purified and tested in guinea pigs and in colophony-sensitive patients. In the modified FCAT method, sensitization was obtained with Portuguese colophony and when challenged with purified abietic acid, the animals showed no reaction. In the GMPT method, the animals were exposed to purified abietic acid. Challenging with 2 different samples of it gave no significant reaction. When patch tested, patients sensitive to colophony showed no reactions to abietic acid which had been purified immediately before the test. It is concluded that abietic acid itself is not a contact allergen.
A T Karlberg; E Bergstedt; A Boman; K Bohlinder; C Lidén; J Lars; G Nilsson; J E Wahlberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  13     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-03-06     Completed Date:  1986-03-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
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MeSH Terms
Allergens / analysis,  toxicity*
Chemical Phenomena
Dermatitis, Contact / diagnosis,  etiology*
Diterpenes / analysis,  toxicity*
Diterpenes, Abietane*
Guinea Pigs
Intradermal Tests
Patch Tests
Resins, Plant / analysis,  toxicity*
Reg. No./Substance:
0/Allergens; 0/Diterpenes; 0/Diterpenes, Abietane; 0/Phenanthrenes; 0/Resins, Plant; 514-10-3/abietic acid; 8050-09-7/rosin

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