Document Detail

abdA expression in Drosophila embryos.
MedLine Citation:
PMID:  1979297     Owner:  NLM     Status:  MEDLINE    
The abdominal A (abdA) gene is one of three transcription units in the Bithorax Complex of Drosophila encoding a homeo box protein; it is flanked by Ultrabithorax (Ubx) and Abdominal B (AbdB). The abdA gene is required for segmental identity of the second through eighth abdominal segments. The transcription unit of abdA is approximately 20 kb long and encodes a protein of 330 amino acids. The abdA homeo box is almost identical to the homeo box of Ubx but is quite different from the AbdB homeo box. A polyclonal antibody to abdA protein stains embryonic nuclei in segments A1-A7 (parasegments 7-13). The iab-2, 3, and 4 mutant classes define positive cis-regulatory elements that induce expression of abdA in segments A2-A4 (parasegments 7-9), respectively. Once a pattern of abdA expression is turned on in a given parasegment, it remains on in the more posterior parasegments, so that the complex pattern of expression is built up in the successive parasegments. The abdA product appears to repress expression of Ubx whenever they appear in the same cell, but abdA is repressed by AbdB only in the eighth and ninth abdominal segments.
F Karch; W Bender; B Weiffenbach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes & development     Volume:  4     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-01-23     Completed Date:  1991-01-23     Revised Date:  2008-10-15    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1573-87     Citation Subset:  IM    
Department of Animal Biology, University of Geneva, Switzerland.
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MeSH Terms
Amino Acid Sequence
Base Sequence
Drosophila / embryology*,  genetics*
Drosophila Proteins*
Gene Expression Regulation
Genes, Homeobox / genetics*
Molecular Sequence Data
Nuclear Proteins*
Protein Biosynthesis
Proteins / genetics*
Transcription Factors*
Reg. No./Substance:
0/Drosophila Proteins; 0/Nuclear Proteins; 0/Proteins; 0/Transcription Factors; 132084-67-4/abd-A protein, Drosophila

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