Document Detail


Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma.
MedLine Citation:
PMID:  22911555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: FoxC1 may promote HCC metastasis through the induction of EMT and the up-regulation of NEDD9 expression. Thus, FoxC1 may be a candidate prognostic biomarker and a target for new therapies.
Authors:
Limin Xia; Wenjie Huang; Dean Tian; Hongwu Zhu; Xingshun Qi; Zheng Chen; Yongguo Zhang; Hao Hu; Daiming Fan; Yongzhan Nie; Kaichun Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-06     Completed Date:  2013-04-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  610-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / biosynthesis
Adult
Animals
Cadherins / biosynthesis
Carcinoma, Hepatocellular / genetics*,  pathology
Cell Line, Tumor
Epithelial-Mesenchymal Transition
Female
Forkhead Transcription Factors / biosynthesis*
Gene Expression Regulation, Neoplastic
Hepatitis B, Chronic / physiopathology
Humans
Liver / metabolism
Liver Neoplasms / genetics*,  pathology
Lung Neoplasms / secondary
Male
Mice
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis / genetics,  physiopathology
Neoplasm Recurrence, Local / physiopathology
Phosphoproteins / biosynthesis
Prognosis
Transcription Factors / biosynthesis
Transcriptional Activation
Tumor Markers, Biological / metabolism
beta Catenin / metabolism
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/Cadherins; 0/FOXC1 protein, human; 0/Forkhead Transcription Factors; 0/NEDD9 protein, human; 0/Phosphoproteins; 0/Transcription Factors; 0/Tumor Markers, Biological; 0/beta Catenin; 0/snail family transcription factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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