| Zygomycosis in neonates: an uncommon but life-threatening infection. | |
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MedLine Citation:
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PMID: 19391079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We systematically reviewed all published cases of zygomycosis, an increasingly important infection with high mortality, in neonates. We searched PubMed and individual references for English publications of single cases or case series of neonatal (0 to 1 month) zygomycosis. Cases were included if they fulfilled prespecified criteria. Fifty-nine cases were published through July 2007. Most of the infants (77%) were premature. The most common sites of zygomycosis were gastrointestinal (54%) and cutaneous (36%) diseases. This pattern differs from sinopulmonary and rhinocerebral patterns of older children. Fifty-six percent of cases were diagnosed by histology only and 44% by histology and culture. RHIZOPUS spp. were isolated from 18/25 (72%) cases. Thirty-seven percent of patients received no antifungal therapy. Thirty-two (54%) neonates underwent surgery with (39%) or without (15%) antifungal agents. Overall mortality was 64%. A higher fraction of neonates treated with amphotericin B and surgery survived than those who received no therapy (70% versus 5%). Zygomycosis is a life-threatening infection in neonates with a distinct pattern of gastrointestinal and cutaneous involvement and high mortality. Combination of amphotericin B and surgery was common management strategy in survivors. |
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Authors:
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Emmanuel Roilides; Theoklis E Zaoutis; Aspasia Katragkou; Daniel K Benjamin; Thomas J Walsh |
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Publication Detail:
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Type: Journal Article; Review Date: 2009-04-23 |
Journal Detail:
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Title: American journal of perinatology Volume: 26 ISSN: 1098-8785 ISO Abbreviation: Am J Perinatol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-17 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 565-73 Citation Subset: IM |
Copyright Information:
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Thieme Medical Publishers. |
Affiliation:
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3rd Department of Pediatrics, Aristotle University, Thessaloniki, Greece. roilides@med.auth.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Humans Infant, Newborn Infant, Premature, Diseases / diagnosis, mortality, therapy Zygomycosis* / diagnosis, mortality, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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