| Zygomycetes infections in pediatric hematology oncology patients: a case series and review of the literature. | |
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MedLine Citation:
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PMID: 19855304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fungi from the Zygomycetes class are increasingly recognized causes of infection in immunosuppressed children, but no comprehensive literature review and few case series have been published on the topic. A case series of 6 pediatric oncology patients with Zygomycetes infections cared for at our institution was constructed, and a concurrent search of the English language literature for Zygomycetes infections in children with oncologic disorders was undertaken. Our case series described 6 patients (5 male) between the ages of 2.5 and 19.5 years. One patient was diagnosed with rhinocerebral disease, 2 with rhinosinusitis, 2 with pulmonary involvement, and 1 with a gastrointestinal presentation. Five patients survived. Our literature review identified 82 cases from 61 studies. The mean subject age was 10.8 years (1.4 to 21.0 y). About 92.7% of all patients suffered from some form of leukemia, with 70.7% suffering from acute lymphoblastic leukemia. Overall, 58.5% of reported patients survived, with individuals with disseminated disease showing the worst prognosis (68.2% mortality) and those with cutaneous disease the best (14.3% mortality). Survival is increasingly reported in the literature, perhaps as a result of improved diagnostic capabilities, increased physician awareness and increased reliance on adjunctive surgical therapy. |
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Authors:
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Walter Dehority; Jennifer Willert; Alice Pong |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of pediatric hematology/oncology Volume: 31 ISSN: 1536-3678 ISO Abbreviation: J. Pediatr. Hematol. Oncol. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-03 Completed Date: 2010-01-07 Revised Date: 2011-10-06 |
Medline Journal Info:
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Nlm Unique ID: 9505928 Medline TA: J Pediatr Hematol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 911-9 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA. WDehority@salud.unm.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Central Nervous System Fungal Infections / complications*, diagnosis, therapy Child Child, Preschool Female Gastrointestinal Diseases / complications*, diagnosis, therapy Hematologic Neoplasms / complications*, diagnosis, therapy Humans Male Paranasal Sinus Diseases / complications*, diagnosis, therapy Prognosis Respiratory Tract Infections / complications*, diagnosis, therapy Survival Rate Young Adult Zygomycosis / complications*, diagnosis, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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