Document Detail

Zygomycetes infections in pediatric hematology oncology patients: a case series and review of the literature.
MedLine Citation:
PMID:  19855304     Owner:  NLM     Status:  MEDLINE    
Fungi from the Zygomycetes class are increasingly recognized causes of infection in immunosuppressed children, but no comprehensive literature review and few case series have been published on the topic. A case series of 6 pediatric oncology patients with Zygomycetes infections cared for at our institution was constructed, and a concurrent search of the English language literature for Zygomycetes infections in children with oncologic disorders was undertaken. Our case series described 6 patients (5 male) between the ages of 2.5 and 19.5 years. One patient was diagnosed with rhinocerebral disease, 2 with rhinosinusitis, 2 with pulmonary involvement, and 1 with a gastrointestinal presentation. Five patients survived. Our literature review identified 82 cases from 61 studies. The mean subject age was 10.8 years (1.4 to 21.0 y). About 92.7% of all patients suffered from some form of leukemia, with 70.7% suffering from acute lymphoblastic leukemia. Overall, 58.5% of reported patients survived, with individuals with disseminated disease showing the worst prognosis (68.2% mortality) and those with cutaneous disease the best (14.3% mortality). Survival is increasingly reported in the literature, perhaps as a result of improved diagnostic capabilities, increased physician awareness and increased reliance on adjunctive surgical therapy.
Walter Dehority; Jennifer Willert; Alice Pong
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  31     ISSN:  1536-3678     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-03     Completed Date:  2010-01-07     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  911-9     Citation Subset:  IM    
Department of Pediatrics, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA.
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MeSH Terms
Central Nervous System Fungal Infections / complications*,  diagnosis,  therapy
Child, Preschool
Gastrointestinal Diseases / complications*,  diagnosis,  therapy
Hematologic Neoplasms / complications*,  diagnosis,  therapy
Paranasal Sinus Diseases / complications*,  diagnosis,  therapy
Respiratory Tract Infections / complications*,  diagnosis,  therapy
Survival Rate
Young Adult
Zygomycosis / complications*,  diagnosis,  therapy

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