Document Detail


ZrO(2) surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry.
MedLine Citation:
PMID:  23218279     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The objective of this study was to modify zirconium dioxide (ZrO(2)) with photo-cured hyaluronic acid hydrogel (pcHAgel), and to subsequently evaluate the bone regeneration potential of the modified ZrO(2). In the present study, HA grafted onto a ZrO(2) substrate was investigated for its biocompatibility and other properties. We describe the positive influences of ZrO(2) surface-modified with pcHAgel (Zr-3) containing two different loads of growth and differentiation factor-5 (GDF-5) to aid new bone formation as compared to the same amount of BMP-2 (Zr-4-7). We characterized the Zr-3 for their surface morphology and chemical properties. Atomic force microscopy (AFM), scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS) showed that the pcHAgel was successfully grafted onto the ZrO(2) surface. The sustained release of GDF-5 and BMP-2 were observed to occur in the Zr-4-7. In vitro cell tests showed a higher level of MG63 cell proliferation and differentiation on Zr-4-7 than on Zr-3. The Zr-3 is a good biomaterial to deliver osteogenic differentiation factors such as BMP-2 and GDF-5, and GDF-5 can be useful as an effective alternative to aid new bone formation as compared to BMP-2.
Authors:
Min Soo Bae; Ji Eun Kim; Jung Bok Lee; Dong Nyoung Heo; Dae Hyeok Yang; Jin-Ho Kim; Kung-Rock Kwon; Jae Beum Bang; Hojae Bae; Il Keun Kwon
Related Documents :
22340359 - Influence of landau level mixing on the properties of elementary excitations in graphen...
23783269 - Mechanism for strong binding of cdse quantum dots to multiwall carbon nanotubes for sol...
24443959 - Photocatalysis deconstructed: design of a new selective catalyst for artificial photosy...
23320759 - Enhancing the interface in silk-polypyrrole composites through chemical modification of...
23106549 - Reactive depth and performance of an electrochemical carbon nanotube network as a funct...
24266229 - Gas sensing studies of pulsed laser deposition deposited wo3 nanorod based thin films.
23201749 - The influence of silicone oil used in ophthalmology on the proton therapy of uveal mela...
22340359 - Influence of landau level mixing on the properties of elementary excitations in graphen...
15885909 - Valence electron energy-loss spectroscopy in monochromated scanning transmission electr...
Publication Detail:
Type:  Journal Article     Date:  2012-10-04
Journal Detail:
Title:  Carbohydrate polymers     Volume:  92     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  167-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Preparation and characterization of hydrogels based on homopolymeric fractions of sodium alginate an...
Next Document:  Controlled antiseptic release by alginate polymer films and beads.