| ZrO(2) surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry. | |
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MedLine Citation:
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PMID: 23218279 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The objective of this study was to modify zirconium dioxide (ZrO(2)) with photo-cured hyaluronic acid hydrogel (pcHAgel), and to subsequently evaluate the bone regeneration potential of the modified ZrO(2). In the present study, HA grafted onto a ZrO(2) substrate was investigated for its biocompatibility and other properties. We describe the positive influences of ZrO(2) surface-modified with pcHAgel (Zr-3) containing two different loads of growth and differentiation factor-5 (GDF-5) to aid new bone formation as compared to the same amount of BMP-2 (Zr-4-7). We characterized the Zr-3 for their surface morphology and chemical properties. Atomic force microscopy (AFM), scanning electron microscope (SEM), and X-ray photoelectron spectroscopy (XPS) showed that the pcHAgel was successfully grafted onto the ZrO(2) surface. The sustained release of GDF-5 and BMP-2 were observed to occur in the Zr-4-7. In vitro cell tests showed a higher level of MG63 cell proliferation and differentiation on Zr-4-7 than on Zr-3. The Zr-3 is a good biomaterial to deliver osteogenic differentiation factors such as BMP-2 and GDF-5, and GDF-5 can be useful as an effective alternative to aid new bone formation as compared to BMP-2. |
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Authors:
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Min Soo Bae; Ji Eun Kim; Jung Bok Lee; Dong Nyoung Heo; Dae Hyeok Yang; Jin-Ho Kim; Kung-Rock Kwon; Jae Beum Bang; Hojae Bae; Il Keun Kwon |
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Publication Detail:
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Type: Journal Article Date: 2012-10-04 |
Journal Detail:
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Title: Carbohydrate polymers Volume: 92 ISSN: 1879-1344 ISO Abbreviation: Carbohydr Polym Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8307156 Medline TA: Carbohydr Polym Country: England |
Other Details:
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Languages: eng Pagination: 167-75 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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