Document Detail


Zosteriform and epidermotropic metastatic primary cutaneous squamous cell carcinoma.
MedLine Citation:
PMID:  11391102     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The first case of primary cutaneous squamous cell carcinoma (SCC) to cause zosteriform and epidermotropic metastasis to skin is reported. The patient is a 72-year-old Japanese woman. A cutaneous SCC appeared on the lateral side of her right knee and was removed. After dissection of the right inguinal lymph nodes, which revealed metastases, and irradiation of the right inguinal region, the patient presented with slightly pruritic and painful erythematous papules on the right hip and small brownish papules and vesicles with crusts on the anterior side of the right thigh. The eruptions were in a zosteriform distribution along the right L1 to L3 dermatomes. Histologically neoplastic squamous cell nests were observed in the epidermis, below the epidermal-dermal junction, and within lymphatic vessels in the deeper reticular dermis. We postulate that neoplastic cells with the ability to fuse with adjacent squamous epithelium may have been carried beneath the basal lamina or to the epidermis via dermal lymphatic backflow, resulting in epidermotropic metastasis.
Authors:
N Kato; S Aoyagi; H Sugawara; M Mayuzumi
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  23     ISSN:  0193-1091     ISO Abbreviation:  Am J Dermatopathol     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-06-06     Completed Date:  2001-08-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  216-20     Citation Subset:  IM    
Affiliation:
Department of Dermatology and Clinical Research Institute, National Sapporo Hospital, Kikusui 4-2, Shiroishi-ku, 003-0804 Sapporo, Japan. kato@sap-cc.go.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Squamous Cell / pathology*,  secondary
Epidermis / pathology
Female
Herpes Zoster / pathology*
Humans
Lymphatic Metastasis
Skin Neoplasms / pathology*

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