Document Detail

Zonula occludens-1 and connexin 43 expression in the failing human heart.
MedLine Citation:
PMID:  17760848     Owner:  NLM     Status:  MEDLINE    
Focal disorganization of gap junctional distribution and down-regulation of the major gap junctional protein connexin 43 are typical features of myocardial remodelling in the failing human heart. Increasing evidence indicates that connexin 43 interacts with zonula-occludens-1 (ZO-1), and it has recently been shown that ZO-1 promotes the formation and growth of gap junctional plaques. In the present study, distribution patterns of ZO-1 and connexin 43 were studied in normal and in heart failure patients using double-label immunohistochemistry and confocal microscopy. ZO-1 was found to be co-localized with connexin 43 at intercalated disks. Importantly, in patients with heart failure due to dilated or ischaemic cardiomyopathy, areas of diminished connexin 43 expression were characterized by a markedly reduced ZO-1 staining. Based on these data it is concluded that in patients with heart failure, down-regulation of ZO-1 matches the diminished expression levels of connexin 43, suggesting that ZO-1 plays an important role in gap junction formation and gap junction plaque stability.
Sawa Kostin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular and molecular medicine     Volume:  11     ISSN:  1582-1838     ISO Abbreviation:  J. Cell. Mol. Med.     Publication Date:    2007 Jul-Aug
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-11-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101083777     Medline TA:  J Cell Mol Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  892-5     Citation Subset:  IM    
Core Lab for Molecular and Structural Biology, W. G. Kerckhoff Institute, Max-Planck Institute for Heart and Lung Research, Parkstrasse 1, 61231 Bad Nauheim, Germany.
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MeSH Terms
Connexin 43 / metabolism*
Heart Failure / metabolism*
Myocardium / metabolism,  pathology
Tight Junctions / metabolism*
Reg. No./Substance:
0/Connexin 43

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