Document Detail

Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study.
MedLine Citation:
PMID:  18367429     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the safety and efficacy of zonisamide in treating myoclonic seizures associated with progressive myoclonic epilepsy (PME), in an open-label setting.
METHODS: Thirty patients with refractory PME (aged > or = 5 years), who were taking up to three antiepileptic drugs, received adjunctive zonisamide (< or = 6 mg/kg/day) therapy for 16 weeks. Myoclonic seizures were recorded daily over a 24-hour period or in 10-minute epochs in the morning, afternoon, and evening. Safety was assessed via adverse events (AEs); efficacy was measured by the percentage of patients experiencing a > or = 50% decrease in myoclonic seizure frequency from baseline.
RESULTS: Treatment-related AEs, experienced by 53% (n = 16/30) of patients, led to five patients discontinuing zonisamide. The most common AEs were decreased appetite, somnolence, and asthenia. Overall, 36% of patients (n = 10/28) had a > or = 50% reduction in myoclonic seizure frequency.
CONCLUSIONS: These results suggest that zonisamide may be useful in the treatment of patients with PME. However, due to the size and open-label character of this study, further research is required.
David G Vossler; Joan A Conry; Jerome V Murphy;
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  10     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-06-23     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  31-4     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / adverse effects,  therapeutic use*
Child, Preschool
Isoxazoles / adverse effects,  therapeutic use*
Myoclonic Epilepsies, Progressive / drug therapy*
Seizures / drug therapy
Reg. No./Substance:
0/Anticonvulsants; 0/Isoxazoles; 68291-97-4/zonisamide
Rose-Mary Boustany / ; Stella Legarda / ; Kevin Ruggles / ; Steven Schachter / ; Krishnamurthy Kaackuzhali / ; Raj Sheth / ; Blanca Vasquez / ; Greg Barkley / ; Harry Chugani / ; Robert Flamini / ; Joseph Sirven / ; Basim Uthman / ; James Wheless / ; Jorge Asconape / ; G Steve Miller / ; John Pellock / ; Colin Van Orman /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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