| Zonisamide for the treatment of myoclonic seizures in progressive myoclonic epilepsy: an open-label study. | |
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MedLine Citation:
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PMID: 18367429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To examine the safety and efficacy of zonisamide in treating myoclonic seizures associated with progressive myoclonic epilepsy (PME), in an open-label setting. METHODS: Thirty patients with refractory PME (aged > or = 5 years), who were taking up to three antiepileptic drugs, received adjunctive zonisamide (< or = 6 mg/kg/day) therapy for 16 weeks. Myoclonic seizures were recorded daily over a 24-hour period or in 10-minute epochs in the morning, afternoon, and evening. Safety was assessed via adverse events (AEs); efficacy was measured by the percentage of patients experiencing a > or = 50% decrease in myoclonic seizure frequency from baseline. RESULTS: Treatment-related AEs, experienced by 53% (n = 16/30) of patients, led to five patients discontinuing zonisamide. The most common AEs were decreased appetite, somnolence, and asthenia. Overall, 36% of patients (n = 10/28) had a > or = 50% reduction in myoclonic seizure frequency. Conclusions: These results suggest that zonisamide may be useful in the treatment of patients with PME. However, due to the size and open-label character of this study, further research is required. |
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Authors:
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David G Vossler; Joan A Conry; Jerome V Murphy; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epileptic disorders : international epilepsy journal with videotape Volume: 10 ISSN: 1294-9361 ISO Abbreviation: Epileptic Disord Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-27 Completed Date: 2008-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891853 Medline TA: Epileptic Disord Country: France |
Other Details:
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Languages: eng Pagination: 31-4 Citation Subset: IM |
Affiliation:
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Epilepsy Center, Washington Neuroscience Institute, Renton, Washington 98055, USA. david_vossler@valleymed.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anticonvulsants / adverse effects, therapeutic use* Child Child, Preschool Female Humans Isoxazoles / adverse effects, therapeutic use* Male Myoclonic Epilepsies, Progressive / drug therapy* Seizures / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Isoxazoles; 68291-97-4/zonisamide |
| Investigator | |
Investigator/Affiliation:
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Rose-Mary Boustany / ; Stella Legarda / ; Kevin Ruggles / ; Steven Schachter / ; Krishnamurthy Kaackuzhali / ; Raj Sheth / ; Blanca Vasquez / ; Greg Barkley / ; Harry Chugani / ; Robert Flamini / ; Joseph Sirven / ; Basim Uthman / ; James Wheless / ; Jorge Asconape / ; G Steve Miller / ; John Pellock / ; Colin Van Orman / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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