Document Detail

Zonisamide - induced urinary lithiasis in patients with intractable epilepsy.
MedLine Citation:
PMID:  10838109     Owner:  NLM     Status:  MEDLINE    
We report here three patients with intractable epilepsy who developed urinary lithiasis during zonisamide (ZNS) treatment. Abdominal pain due to left-sided hydronephrosis was the initial symptom in the first patient, and it was resolved after the excretion of a stone. The second patient, who had no specific symptoms, was found to have a thick sludge of calcium phosphate in the bladder when he suffered from aspiration pneumonia and dehydration. The third patient, who had a history of recurrent urinary obstruction, was also found to have a thick sludge of calcium oxalate in the bladder. The urinalysis of the three patients revealed alkaline urine and hypercalciuria. Although their urinary lithiasis was resolved by discontinuation of ZNS and supportive therapy, routine examination of urine parameters such as pH and sediments, and daily urine-output checks are thought to be necessary during treatment with ZNS, especially for patients who are bedridden for a long time and receive multiple antiepileptic drugs.
M Kubota; M Nishi-Nagase; Y Sakakihara; S Noma; M Nakamoto; H Kawaguchi; M Yanagisawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  22     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-24     Completed Date:  2000-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  230-3     Citation Subset:  IM    
Department of Pediatrics, University of Tokyo, Japan.
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MeSH Terms
Anticonvulsants / adverse effects*
Hydronephrosis / chemically induced,  ultrasonography
Isoxazoles / adverse effects*
Kidney Calculi / chemically induced*,  ultrasonography
Spasms, Infantile / drug therapy*
Reg. No./Substance:
0/Anticonvulsants; 0/Isoxazoles; 68291-97-4/zonisamide
Comment In:
Brain Dev. 2000 Oct;22(7):460   [PMID:  11221704 ]

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