Document Detail


Zonisamide concentrations during pregnancy.
MedLine Citation:
PMID:  18577760     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe a series of serum concentrations of zonisamide in a pregnant woman. CASE SUMMARY: A 30-year-old woman with primary generalized tonic-clonic seizures and myoclonic jerks was taking zonisamide 200 mg daily as her sole antiepileptic agent when she conceived. She continued on zonisamide throughout her pregnancy. The zonisamide concentrations ranged between 7.5 microg/mL and 17 microg/mL during pregnancy, with the exception of a 4.4-microg/mL concentration at 27 weeks postconception. Following this lower concentration, the zonisamide dose was increased to 300 mg/day at week 29. She had an uneventful pregnancy, with only occasional myoclonic jerks, and delivered at 41 weeks. At 42 weeks, while taking zonisamide 300 mg/day, her concentration was 20.8 microg/mL. DISCUSSION: A single report from Japan reviewed 26 cases of prenatal exposure to zonisamide. Twenty-two offspring were exposed to zonisamide monotherapy; 4 were exposed to polytherapy. During the first trimester, 2 pregnant women on zonisamide and at least one other antiepileptic medication had serum concentrations of 6.1 microg/mL and 6.2 microg/mL; 2 of the infants had teratogenic effects. Teratogenicity has also been reported in animals. There are no other published data regarding zonisamide concentrations during pregnancy. CONCLUSIONS: The change in zonisamide serum concentrations in a pregnant woman suggests an increase in clearance at the end of the second trimester.
Authors:
Karen S Oles; William L Bell
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-06-24
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  42     ISSN:  1542-6270     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-13     Completed Date:  2008-09-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1139-41     Citation Subset:  IM    
Affiliation:
Department of Neurology, Pharmacy Education, Northwest Area Health Education Center, School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA. koles@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / blood*,  therapeutic use*
Female
Humans
Isoxazoles / blood*,  therapeutic use*
Myoclonic Epilepsy, Juvenile / drug therapy*
Pregnancy
Pregnancy Complications / drug therapy*
Seizures / drug therapy*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Isoxazoles; 68291-97-4/zonisamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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