| Zone-specific hepatotoxicity of gossypol in perfused rat liver. | |
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MedLine Citation:
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PMID: 1926180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gossypol selectively damages the periportal region of lobules in perfused rat liver, while retrograde perfusion caused pericentral liver damage. Moreover, the addition of 0.4% bovine serum albumin(BSA) to the perfusate completely prevented the toxic effect of gossypol on hepatocytes, decreasing the absorption of gossypol by the liver. This study indicates that the damage caused by gossypol depends upon the direction of exposure and can be protected against by its binding to BSA. |
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Authors:
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S Manabe; D C Nuber; Y C Lin |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 29 ISSN: 0041-0101 ISO Abbreviation: Toxicon Publication Date: 1991 |
Date Detail:
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Created Date: 1991-11-21 Completed Date: 1991-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 787-90 Citation Subset: IM |
Affiliation:
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Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Ohio State University, Columbus 43210. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aspartate Aminotransferases / blood Gossypol / antagonists & inhibitors, toxicity* L-Lactate Dehydrogenase / blood Liver / drug effects* Male Perfusion Rats Rats, Inbred Strains Serum Albumin, Bovine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin, Bovine; 303-45-7/Gossypol; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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