| Zonation of the action of glucagon on gluconeogenesis studied in the bivascularly perfused rat liver. | |
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MedLine Citation:
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PMID: 7925934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have measured the action of glucagon, infused into the hepatic artery, on gluconeogenesis from lactate in the rat liver, bivascularly perfused in both the anterograde and retrograde modes. Concerning glucose production and oxygen uptake per unit cell space, the response of the periportal cells reached via the hepatic artery in retrograde perfusion to glucagon is superior to the response of the cells reached via the same vessel in anterograde perfusion. This phenomenon, however, most probably reflects zonation of gluconeogenesis rather than zonation of the hormonal action. The latter conclusion is based on the observation that the fractional change caused by the hormone is the same for all liver cells. |
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Authors:
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J Constantin; E Ishii-Iwamoto; F Suzuki-Kemmelmeier; A Bracht |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 352 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-10-25 Completed Date: 1994-10-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 24-6 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Maringá, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albinism Animals Glucagon / pharmacology* Gluconeogenesis / drug effects* Glucose / biosynthesis Hepatic Artery / metabolism Lactates / metabolism Lactic Acid Liver / cytology, metabolism* Male Oxygen Consumption Perfusion Pyruvates / metabolism Pyruvic Acid Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 50-99-7/Glucose; 9007-92-5/Glucagon |
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