Document Detail

Zolpidem-related effects on performance and mood during simulated night-shift work.
MedLine Citation:
PMID:  14599259     Owner:  NLM     Status:  MEDLINE    
The effects of zolpidem, a nonbenzodiazepine hypnotic, on psychomotor task performance, subjective effects, and food intake were examined during simulated shift work. Seven participants completed this 23-day, within-participant design, residential laboratory study. They received a single oral zolpidem dose (0, 5, or 10 mg) 1 hr before bedtime for 3 consecutive days under 2 shift conditions: day shift and night shift. When participants received placebo, next-day performance and subjective effects were disrupted, and food intake was decreased during the night shift. Zolpidem improved subjective reports of sleep quality and, to a lesser extent, next-day performance. Next-day mood, however, was worsened by zolpidem. Food intake was unaffected by zolpidem. These data indicate that shift changes produce performance impairments, mood alterations, and decreases in food intake, and that zolpidem attenuates some shift-change-related disruptions.
Carl L Hart; Amie S Ward; Margaret Haney; Richard W Foltin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental and clinical psychopharmacology     Volume:  11     ISSN:  1064-1297     ISO Abbreviation:  Exp Clin Psychopharmacol     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-05     Completed Date:  2004-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9419066     Medline TA:  Exp Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-68     Citation Subset:  IM    
Department of Psychiatry, New York State Psychiatric Institute and College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.
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MeSH Terms
Affect / drug effects*
Analysis of Variance
Area Under Curve
Dose-Response Relationship, Drug
Eating / drug effects
Hypnotics and Sedatives / pharmacology*,  therapeutic use
Psychomotor Performance / drug effects*
Pyridines / pharmacology*,  therapeutic use
Sleep / drug effects
Sleep Disorders, Circadian Rhythm / drug therapy,  physiopathology
Work Schedule Tolerance
Grant Support
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Pyridines; 82626-48-0/zolpidem

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