Document Detail


Zolpidem (Ambien) in pregnancy: placental passage and outcome.
MedLine Citation:
PMID:  19657707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the extent and clinical sequelae of fetal exposure to zolpidem, a commonly prescribed hypnotic agent. Pregnant women with psychiatric illness participating in a study of psychotropic pharmacokinetics were included. Zolpidem concentrations were analyzed in maternal and umbilical cord plasma collected at delivery. Outcomes were compared between the zolpidem-exposed group and a 1:1 matched comparator group. Forty-five women taking zolpidem during pregnancy were studied. Rates of preterm delivery and low birth weight were 26.7% and 15.6% respectively in the zolpidem-exposed group versus 13.3% and 4.4% in the matched comparator group, but no significant differences were found. The ratio of umbilical cord to maternal plasma zolpidem concentrations in 6 pairs ranged from 0.48 to 2.75. Zolpidem crosses the human placenta and rapidly clears the fetal circulation. Pregnant women with psychiatric illness treated with zolpidem may have less optimal obstetrical outcome, though it is unclear if this was related to the medication.
Authors:
Sandra Juric; D Jeffrey Newport; James C Ritchie; Melanie Galanti; Zachary N Stowe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-08-06
Journal Detail:
Title:  Archives of women's mental health     Volume:  12     ISSN:  1435-1102     ISO Abbreviation:  Arch Womens Ment Health     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815663     Medline TA:  Arch Womens Ment Health     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
Affiliation:
Dept. of Psychiatry & Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Humans
Hypnotics and Sedatives / administration & dosage*,  adverse effects
Infant, Low Birth Weight
Infant, Newborn
Maternal-Fetal Exchange / drug effects*
Obstetric Labor, Premature
Placental Circulation
Pregnancy
Pregnancy Outcome / epidemiology*
Pyridines / administration & dosage*,  adverse effects
Young Adult
Grant Support
ID/Acronym/Agency:
MH-68036/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Hypnotics and Sedatives; 0/Pyridines; 82626-48-0/zolpidem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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