| Zoledronic acid treatment in children with osteogenesis imperfecta. | |
| | |
MedLine Citation:
|
PMID: 21293106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Intravenous disodium pamidronate has become an established treatment in osteogenesis imperfecta (OI). Another bisphosphonate, zoledronic acid, has been indicated for the treatment of adult osteoporosis. We studied its efficacy and safety in children with mild OI. METHODS: Patients were treated for 1.0-3.2 years with 0.05 mg/kg zoledronic acid intravenously every 6 months as part of their clinical care. They were carefully followed for clinical and biochemical parameters, side effects, bone mineral densities (BMD) and compression fractures. RESULTS: The study included 17 patients (age 1.5-16.8 years) with type I OI. They had sustained altogether 73 fractures; 9 had compression fractures. During the treatment, 6 patients suffered in total 10 new long-bone fractures. The median lumbar spine areal BMD z-score increased from -2.0 to -0.7 during 2 years of treatment. The infusions were associated with a transient decrease in serum calcium and phosphate and a significant increase in serum PTH. Two patients developed symptomatic hypocalcemia. Bone turnover markers decreased during the treatment. CONCLUSIONS: Intravenous zoledronic acid is an effective mode of treatment in children with OI. The treatment response is comparable to pamidronate but the infusion protocol is more convenient. Further studies are needed to establish optimal dosing and long-term safety. |
| | |
Authors:
|
Ilkka Vuorimies; Sanna Toiviainen-Salo; Matti Hero; Outi Mäkitie |
Related Documents
:
|
17342286 - Effects of vitamin e supplementation on bone metabolism in nicotine-treated rats. 21385106 - Risk of osteoporosis and fracture incidence in patients on antipsychotic medication. 21480536 - Characterization of the anchoring morphology and mineral content of the anterior crucia... 21144926 - The biology of intramedullary reaming. 8410236 - Supraorbital craniotomy by fracture of the anterior orbital roof. technical note. 1563156 - Tibial fractures. the ilizarov alternative. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-02-02 |
Journal Detail:
|
Title: Hormone research in pædiatrics Volume: 75 ISSN: 1663-2826 ISO Abbreviation: Horm Res Paediatr Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-05-04 Completed Date: 2011-08-23 Revised Date: 2011-12-01 |
Medline Journal Info:
|
Nlm Unique ID: 101525157 Medline TA: Horm Res Paediatr Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 346-53 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Hospital for Children and Adolescents, Pediatric Endocrinology and Metabolic Bone Diseases, University of Helsinki, Helsinki, Finland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Bone Density / drug effects Bone Density Conservation Agents / therapeutic use Child Child, Preschool Diphosphonates / therapeutic use* Female Follow-Up Studies Fractures, Bone / epidemiology, prevention & control Humans Imidazoles / therapeutic use* Infant Lumbar Vertebrae / drug effects Male Osteogenesis Imperfecta / drug therapy* Spinal Fractures / epidemiology, prevention & control Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Bone Density Conservation Agents; 0/Diphosphonates; 0/Imidazoles; 118072-93-8/zoledronic acid |
| Comments/Corrections | |
Comment In:
|
Horm Res Paediatr. 2011;76(4):291; author reply 292
[PMID:
21912084
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Maternal Serum Adiponectin at 11-13 Weeks of Gestation in Pregnancies Delivering Small for Gestation...
Next Document: Calcipotriol plus Betamethasone Dipropionate Gel Compared with Tacalcitol Ointment and the Gel Vehic...