Document Detail

ZnS quantum dots derived a reagentless uric acid biosensor.
MedLine Citation:
PMID:  18970471     Owner:  NLM     Status:  In-Data-Review    
A reagentless amperometric uric acid biosensor based on zinc sulfide (ZnS) quantum dots (QDs) was firstly developed. It could detect uric acid without the presence of an electron mediator. The carboxyl group functionalized ZnS QDs were synthesized, and they were soluble biocompatible and conductive. ZnS QDs conjugates could provide increased enzyme binding sites, which may result in higher enzyme loading. Thus, the proposed uricase/ZnS QDs/l-cys biosensor exhibited higher amperometric response compared to the one without QDs (uricase/l-cys biosensor). In addition, there was little AA interference. It showed a linear dependence on the uric acid concentration ranging from 5.0x10(-6) to 2.0x10(-3)molL(-1) with a detection limit of 2.0x10(-6)molL(-1) at 3sigma.
Fenfen Zhang; Chenxin Li; Xiaohua Li; Xiaoli Wang; Qiao Wan; Yuezhong Xian; Litong Jin; Katsunobu Yamamoto
Publication Detail:
Type:  Journal Article     Date:  2005-09-15
Journal Detail:
Title:  Talanta     Volume:  68     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2008-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  1353-8     Citation Subset:  -    
Department of Chemistry, East China Normal University, Shanghai 200062, China.
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