| Zn²+ chelation improves recovery by delaying spreading depression-like events. | |
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MedLine Citation:
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PMID: 20856149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We earlier reported that Zn²+ chelation improved recovery of synaptic potentials after transient oxygen and glucose deprivation in brain slices. Such an effect could be because of reduced accumulation of Zn²+ in postsynaptic neurons, or could also be due to prevention of the onset of spreading depression-like events. A combination of optical and electrical recording was used here to show that Zn²+ chelation is effective because it delays spreading depression-like events. If the duration of oxygen/glucose deprivation was sufficient to generate a spreading depression-like event, irrecoverable Ca²+-dependent loss of synaptic potentials occurred, regardless of Zn²+ availability. These results identify a key mechanism underlying protective effects of Zn²+ chelation, and emphasize the importance of evaluating spreading depression-like events in studies of neuroprotection. |
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Authors:
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Russell E Carter; John H Weiss; C William Shuttleworth |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Neuroreport Volume: 21 ISSN: 1473-558X ISO Abbreviation: Neuroreport Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2011-08-15 Revised Date: 2013-01-18 |
Medline Journal Info:
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Nlm Unique ID: 9100935 Medline TA: Neuroreport Country: England |
Other Details:
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Languages: eng Pagination: 1060-4 Citation Subset: IM |
Affiliation:
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Department of Neurosciences, University of New Mexico, Albuquerque, New Mexico, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chelating Agents / pharmacology*, therapeutic use Cortical Spreading Depression / drug effects, physiology* Female Hypoxia-Ischemia, Brain / drug therapy*, metabolism* Male Mice Mice, Inbred C57BL Neuroprotective Agents / pharmacology*, therapeutic use Organ Culture Techniques Zinc / antagonists & inhibitors*, metabolism*, toxicity |
| Grant Support | |
ID/Acronym/Agency:
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NS051288/NS/NINDS NIH HHS; NS065219/NS/NINDS NIH HHS; R01 NS051288/NS/NINDS NIH HHS; R01 NS051288-06/NS/NINDS NIH HHS; R01 NS065219-02/NS/NINDS NIH HHS; T32HL007736/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Neuroprotective Agents; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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