Document Detail


Zn²+ chelation improves recovery by delaying spreading depression-like events.
MedLine Citation:
PMID:  20856149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We earlier reported that Zn²+ chelation improved recovery of synaptic potentials after transient oxygen and glucose deprivation in brain slices. Such an effect could be because of reduced accumulation of Zn²+ in postsynaptic neurons, or could also be due to prevention of the onset of spreading depression-like events. A combination of optical and electrical recording was used here to show that Zn²+ chelation is effective because it delays spreading depression-like events. If the duration of oxygen/glucose deprivation was sufficient to generate a spreading depression-like event, irrecoverable Ca²+-dependent loss of synaptic potentials occurred, regardless of Zn²+ availability. These results identify a key mechanism underlying protective effects of Zn²+ chelation, and emphasize the importance of evaluating spreading depression-like events in studies of neuroprotection.
Authors:
Russell E Carter; John H Weiss; C William Shuttleworth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Neuroreport     Volume:  21     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-14     Completed Date:  2011-08-15     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  1060-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chelating Agents / pharmacology*,  therapeutic use
Cortical Spreading Depression / drug effects,  physiology*
Female
Hypoxia-Ischemia, Brain / drug therapy*,  metabolism*
Male
Mice
Mice, Inbred C57BL
Neuroprotective Agents / pharmacology*,  therapeutic use
Organ Culture Techniques
Zinc / antagonists & inhibitors*,  metabolism*,  toxicity
Grant Support
ID/Acronym/Agency:
NS051288/NS/NINDS NIH HHS; NS065219/NS/NINDS NIH HHS; R01 NS051288/NS/NINDS NIH HHS; R01 NS051288-06/NS/NINDS NIH HHS; R01 NS065219/NS/NINDS NIH HHS; T32HL007736/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Neuroprotective Agents; J41CSQ7QDS/Zinc
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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