Document Detail


Ziprasidone overdose: cases recorded in the database of Pfizer-Spain and literature review.
MedLine Citation:
PMID:  16232029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ziprasidone is an atypical antipsychotic with a highly specific receptorbinding profile that has been shown to be effective for both positive and negative symptoms of schizophrenia. The agent has been associated with a low frequency of extrapyramidal symptoms and sedative and anticholinergic effects. Four cases of acute ziprasidone overdose were recorded in the database of the department of pharmacovigilance of Pfizer-Spain from January 2003 (when ziprasidone was first marketed in Spain) to October 2004. The doses taken were 780, 1120, 4400, and 4480 mg. In two cases, an excessive ingestion of other drugs such as benzodiazepines and sedative hypnotics was also noted. None of the four cases showed cardiac adverse effects, and the QTc interval was within the normal range in all patients. No relevant neurologic clinical signs were observed, except for mild drowsiness in three cases. Evaluation of these four cases, as well as review of the literature, showed that an overdose of ziprasidone alone, in patients without risk factors that contraindicate its use, is relatively safe.
Authors:
María Soledad Gómez-Criado; Miguel Bernardo; Tomas de Florez; José Ramón Gutiérrez; Ricardo Gandía; Ignacio Ayani
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pharmacotherapy     Volume:  25     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-19     Completed Date:  2006-02-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1660-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacovigilance, Pfizer-Spain, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antipsychotic Agents / poisoning*
Databases as Topic
Electrocardiography / drug effects
Female
Humans
Male
Middle Aged
Overdose
Piperazines / poisoning*
Thiazoles / poisoning*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Piperazines; 0/Thiazoles; 146939-27-7/ziprasidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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