| Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes. | |
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MedLine Citation:
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PMID: 22069281 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to determine the prevalence and role of autoantibodies to zinc transporter 8 (ZnT8A) in three forms (fulminant, acute-onset, and slow-onset) of Japanese patients with type 1 diabetes. METHODS: One-hundred and ninety-six new-onset patients with type 1 diabetes were studied: 85 were fulminant, 81 acute-onset, and 30 slow-onset type 1 diabetes. ZnT8A were determined by radioimmunoassay using a hybrid ZnT8 carboxy-terminal construct (aa268-369) carrying 325Trp and 325Arg. Furthermore, ZnT8A epitopes were analysed using ZnT8 constructs incorporating the known aa325 variants (Trp, Arg, and Gln). RESULTS: ZnT8A were detected in 58% patients with acute-onset and 20% with slow-onset type 1 diabetes (p < 0.0005). In contrast, none of sera from fulminant type 1 diabetes were reactive to ZnT8 construct. Conversion of Arg or Trp to Gln at aa325 abolished reactivity in 59% of patients with an age of onset > 10 years, which was significantly higher than that in patients ⩽10 years of age (33%, p < 0.05). CONCLUSIONS: These results suggest that ZnT8A are an additional useful marker for acute-onset type 1 diabetes, but not a diagnostic marker for fulminant type 1 diabetes, and ZnT8A epitope recognition is different according to the onset age. Copyright © 2011 John Wiley & Sons, Ltd. |
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Authors:
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Eiji Kawasaki; Kan Nakamura; Genpei Kuriya; Tsuyoshi Satoh; Masakazu Kobayashi; Hironaga Kuwahara; Norio Abiru; Hironori Yamasaki; Nobuo Matsuura; Junnosuke Miura; Yasuko Uchigata; Katsumi Eguchi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: 27 ISSN: 1520-7560 ISO Abbreviation: Diabetes Metab. Res. Rev. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: England |
Other Details:
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Languages: eng Pagination: 895-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Metabolism/Diabetes and Clinical Nutrition, Nagasaki University Hospital, Nagasaki, Japan. eijikawa@nagasaki-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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