Document Detail


Zinc therapy in otology.
MedLine Citation:
PMID:  979493     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
At a recent panel on Otology, I asked the audience for a show of hands of those using Zinc for delayed healing and granulations. It was surprising to note that not more than 4 physicians out of 100 had tried Zinc. The need to report our encouraging results was apparent. From 1971 to 1975, 544 tympanoplasties and 122 mastoidectomies were studied for delayed healing due to granulations. Forty-six patients were found to have resistant granulations. Thirty-three of these healed within two weeks of therapy, 10 more required a total of four weeks for healing, and three did not respond well. Sixteen patients had recurrence when the medication was terminated as soon as healing had occurred but responded well when the medication was continued for four weeks after healing was complete. Five patients had nausea, which subsided when the dosage was reduced from the usual 200 mg. of Zinc Sulfate, three times daily with meals to 100 mg., t.i.d. or b.i.d. One patient developed mild urticaria. Zinc therapy is apparently indicated in granulomata of the ear when healing does not occur with conventional therapy, especially in the post-operative patient; however, it will not suffice when there is massive involvement of the mastoid or middle ear, where surgical removal is indicated.
Authors:
R L Ruggles; P A Linquist
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Laryngoscope     Volume:  86     ISSN:  0023-852X     ISO Abbreviation:  Laryngoscope     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1688-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Child
Ear Diseases / drug therapy*
Female
Granulation Tissue / drug effects
Humans
Male
Mastoid / surgery
Middle Aged
Tympanoplasty
Wound Healing
Zinc / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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