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Zinc therapy improves deleterious effects of chronic copper administration on mice testes: histopathological evaluation.
MedLine Citation:
PMID:  23137167     Owner:  NLM     Status:  Publisher    
This study was set to investigate whether the adverse effects of long-term copper (Cu) consumption on testicular tissue could be prevented by zinc (Zn) administration. Forty-five mature male rats were randomly divided into one control and two treatment groups. The first treatment group received copper sulfate (Cu experimental group). The second treatment group was given combined treatment of copper sulfate and zinc sulfate (ZC experimental group). Control animals received normal saline using the same volume. Five rats from each group were sacrificed on day 14, 28 and 56 from the beginning of treatments. Left testes were removed for histopathological and histomorphometrical evaluations. Morphometrically, diameter of seminiferous tubules and sertoli cells nuclei, epithelial height, meiotic index and the percentage of spermatogenesis in Cu groups showed significant decrease than those of the control groups (P < 0.05). A partial improvement was seen about the percentage of spermatogenesis and meiotic index (P < 0.05) in ZC groups, whereas a complete recovery was observed in the rest of parameters in ZC group after 56 days compared to the control group (P > 0.05). Results showed that long-term administration of Cu leads to histological impairments of testis and zinc supplementation might offset these damaging effects.
R Kheirandish; N Askari; H Babaei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Andrologia     Volume:  -     ISSN:  1439-0272     ISO Abbreviation:  Andrologia     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran.
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