Document Detail

Zinc therapy of acetazolamide-induced side-effects.
MedLine Citation:
PMID:  6391074     Owner:  NLM     Status:  MEDLINE    
A double-blind cross-over trial extending over 4 weeks with administration of 0.2 g zinc sulphate 3 times daily and a placebo was carried out on 12 patients having grave acetazolamide-induced side-effects manifesting themselves as gustatory disorder, anorexia, and paraesthesia. All the patients had S-zinc levels within the normal range. These rose during zinc therapy periods, to fall again within placebo periods. Recording of the degrees of subjective side-effects based on interviews showed the side-effects to abate towards the conclusion of the trial period, independently of the randomizing programme. In other words, no significant difference was demonstrable between zinc period and placebo period. Taste tests according to Börnstein showed the gustatory disorders to be related exclusively to beverages containing carbon dioxide. However, in no more than 3 out of 10 patients did the gustatory sense return to normal after administration of zinc and one after placebo. Thus, this controlled trial has not served to disclose any statistically significant effect of zinc administration on acetazolamide-induced side-effects.
H Dahl; K Nørskov; E Peitersen; J Hilden
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  62     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-01-18     Completed Date:  1985-01-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  739-45     Citation Subset:  IM    
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MeSH Terms
Acetazolamide / adverse effects*
Anorexia / chemically induced,  drug therapy*
Clinical Trials as Topic
Double-Blind Method
Eating Disorders / drug therapy*
Middle Aged
Paresthesia / chemically induced,  drug therapy*
Sulfates / blood,  therapeutic use*
Taste Disorders / chemically induced,  drug therapy*
Zinc / blood,  therapeutic use*
Zinc Sulfate
Reg. No./Substance:
0/Sulfates; 59-66-5/Acetazolamide; 7440-66-6/Zinc; 7733-02-0/Zinc Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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