| Zinc therapy of acetazolamide-induced side-effects. | |
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MedLine Citation:
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PMID: 6391074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind cross-over trial extending over 4 weeks with administration of 0.2 g zinc sulphate 3 times daily and a placebo was carried out on 12 patients having grave acetazolamide-induced side-effects manifesting themselves as gustatory disorder, anorexia, and paraesthesia. All the patients had S-zinc levels within the normal range. These rose during zinc therapy periods, to fall again within placebo periods. Recording of the degrees of subjective side-effects based on interviews showed the side-effects to abate towards the conclusion of the trial period, independently of the randomizing programme. In other words, no significant difference was demonstrable between zinc period and placebo period. Taste tests according to Börnstein showed the gustatory disorders to be related exclusively to beverages containing carbon dioxide. However, in no more than 3 out of 10 patients did the gustatory sense return to normal after administration of zinc and one after placebo. Thus, this controlled trial has not served to disclose any statistically significant effect of zinc administration on acetazolamide-induced side-effects. |
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Authors:
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H Dahl; K Nørskov; E Peitersen; J Hilden |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta ophthalmologica Volume: 62 ISSN: 0001-639X ISO Abbreviation: Acta Ophthalmol (Copenh) Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1985-01-18 Completed Date: 1985-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370347 Medline TA: Acta Ophthalmol (Copenh) Country: DENMARK |
Other Details:
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Languages: eng Pagination: 739-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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adverse effects* Aged Anorexia / chemically induced, drug therapy* Clinical Trials as Topic Double-Blind Method Eating Disorders / drug therapy* Female Humans Male Middle Aged Paresthesia / chemically induced, drug therapy* Sulfates / blood, therapeutic use* Taste Disorders / chemically induced, drug therapy* Zinc / blood, therapeutic use* Zinc Sulfate |
| Chemical | |
Reg. No./Substance:
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0/Sulfates; 59-66-5/Acetazolamide; 7440-66-6/Zinc; 7733-02-0/Zinc Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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