Document Detail


Zinc status in patients with alveolar echinococcosis is related to disease progression.
MedLine Citation:
PMID:  10320621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Zinc is an essential trace element for immune function that plays a role in immune response against parasites. To determine a possible relationship between zinc level and disease status in alveolar echinococcosis (AE), we investigated serum concentrations of zinc, immunoglobulin (Ig)E, IgG, and C-reactive protein (CRP) in 40 AE patients and 20 controls. Patients were classified into three groups: group A: patients after curative surgery, group B: patients with stabilized disease, group C: patients with progressive disease. Patients showed significantly higher levels of IgE and IgG than controls. Amounts of IgE and IgG were related to disease severity, achieving highest levels in group C and lowest in group A. Zinc levels were comparable in patients and controls. However, there was an obvious association between zinc concentration and disease severity. Zinc was far below the normal range in group C (median 9.2 micromol/l) and significantly diminished compared to group B and controls. An inverse pattern was seen for CRP. In conclusion, lowered zinc concentration in progressive cases may be caused by enhanced immune activation but consumption of zinc by the growing parasite may also play a role. Furthermore, decreased zinc levels may contribute to the observed immunosuppression in AE.
Authors:
N Wellinghausen; W Jöchle; S Reuter; W A Flegel; A Grünert; P Kern
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Parasite immunology     Volume:  21     ISSN:  0141-9838     ISO Abbreviation:  Parasite Immunol.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-02     Completed Date:  1999-07-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910948     Medline TA:  Parasite Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-41     Citation Subset:  IM    
Affiliation:
Section of Infectious Diseases and Clinical Immunology, University of Ulm, Robert-Koch-Strasse 8, 89081 Ulm, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Animals
Antibodies, Helminth / blood
C-Reactive Protein / analysis
Disease Progression
Echinococcosis, Pulmonary / blood*,  immunology*,  surgery
Echinococcus / immunology
Female
Host-Parasite Interactions
Humans
Immunoglobulin E / blood
Immunoglobulin G / blood
Male
Middle Aged
Zinc / blood*,  immunology
Chemical
Reg. No./Substance:
0/Antibodies, Helminth; 0/Immunoglobulin G; 37341-29-0/Immunoglobulin E; 7440-66-6/Zinc; 9007-41-4/C-Reactive Protein

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